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• W2898692566 abstract "For efficacy of peptide vaccination immunotherapy for patients with cancer, endogenous expression of the target peptide/human leukocyte antigen ( HLA ) on cancer cells is required. However, it is difficult to evaluate the expression status of a peptide/ HLA complex because of the lack of a soluble T‐cell receptor ( TCR ) that reacts with tumor‐associated antigen ( TAA ) with high avidity. In the present study, we developed two soluble TCR ‐multimers that were each directed to TAA , survivin‐2B (SVN‐2B) and PBF in the context of HLA ‐A24 ( SVN ‐2B TCR ‐multimer and PBF TCR ‐multimer, respectively), from CTL clones that were established from peptide‐vaccinated patients. Both TCR multimers could recognize cognate peptide‐pulsed antigen‐presenting cells, C1R‐A24 cells, in a CD 8‐independent method. Moreover, the PBF TCR ‐multimer successfully recognized a PBF peptide naturally presented on HLA ‐A24 + PBF + osteosarcoma cells. Taken together, the results indicated that a TCR ‐multimer might be useful for detection of a TAA ‐derived peptide presented by HLA in patients receiving immunotherapy." @default.
• W2898692566 created "2018-11-09" @default.
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• W2898692566 date "2018-12-01" @default.
• W2898692566 modified "2023-09-25" @default.
• W2898692566 title "Development of a T-cell receptor multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells" @default.
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• W2898692566 doi "https://doi.org/10.1111/cas.13854" @default.
• W2898692566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6317924" @default.
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