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• W2898714372 abstract "Hypsizygus marmoreus (Beech mushroom) is a popular ingredient in Asian cuisine. The medicinal effects of its bioactive compounds such as hypsin and hypsiziprenol have been reported, but the genetic basis or biosynthesis of these components is unknown. In this study, we sequenced a reference strain of H. marmoreus (Haemi 51,987–8). We evaluated various assembly strategies, and as a result the Allpaths and PBJelly produced the best assembly. The resulting genome was 42.7 Mbp in length and annotated with 16,627 gene models. A putative gene (Hypma_04324) encoding the antifungal and antiproliferative hypsin protein with 75% sequence identity with the previously known N-terminal sequence was identified. Carbohydrate active enzyme analysis displayed the typical feature of white-rot fungi where auxiliary activity and carbohydrate-binding modules were enriched. The genome annotation revealed four terpene synthase genes responsible for terpenoid biosynthesis. From the gene tree analysis, we identified that terpene synthase genes can be classified into six clades. Four terpene synthase genes of H. marmoreus belonged to four different groups that implies they may be involved in the synthesis of different structures of terpenes. A terpene synthase gene cluster was well-conserved in Agaricomycetes genomes, which contained known biosynthesis and regulatory genes. Genome sequence analysis of this mushroom led to the discovery of the hypsin gene. Comparative genome analysis revealed the conserved gene cluster for terpenoid biosynthesis in the genome. These discoveries will further our understanding of the biosynthesis of medicinal bioactive molecules in this edible mushroom." @default.
• W2898714372 created "2018-11-09" @default.
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• W2898714372 date "2018-11-01" @default.
• W2898714372 modified "2023-10-14" @default.
• W2898714372 title "Genomic discovery of the hypsin gene and biosynthetic pathways for terpenoids in Hypsizygus marmoreus" @default.
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• W2898714372 doi "https://doi.org/10.1186/s12864-018-5159-y" @default.
• W2898714372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6211417" @default.
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