FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898715082> ?p ?o ?g. }

• W2898715082 abstract "Abstract After decades of study in humans and animal models, there remains a lack of consensus regarding how the action of electrical stimulation on neuronal and non-neuronal elements – e.g. neuropil, cell bodies, glial cells, etc. – leads to the therapeutic effects of neuromodulation therapies. To further our understanding of neuromodulation therapies, there is a critical need for novel methodological approaches using state-of-the-art neuroscience tools to study neuromodulation therapy in preclinical models of disease. In this manuscript we outline one such approach combining chronic behaving single-photon microendoscope recordings in a pathological mouse model with electrical stimulation of a common deep brain stimulation (DBS) target. We describe in detail the steps necessary to realize this approach, as well as discuss key considerations for extending this experimental paradigm to other DBS targets for different therapeutic indications. Additionally, we make recommendations from our experience on implementing and validating the required combination of procedures that includes: the induction of a pathological model (6-OHDA model of Parkinson’s disease) through an injection procedure, the injection of the viral vector to induce GCaMP expression, the implantation of the GRIN lens and stimulation electrode, and the installation of a baseplate for mounting the microendoscope. We proactively identify unique data analysis confounds occurring due to the combination of electrical stimulation and optical recordings and outline an approach to address these confounds. In order to validate the technical feasibility of this unique combination of experimental methods, we present data to demonstrate that 1) despite the complex multifaceted surgical procedures, chronic optical recordings of hundreds of cells combined with stimulation is achievable over week long periods 2) this approach enables measurement of differences in DBS evoked neural activity between anesthetized and awake conditions and 3) this combination of techniques can be used to measure electrical stimulation induced changes in neural activity during behavior in a pathological mouse model. These findings are presented to underscore the feasibility and potential utility of minimally constrained optical recordings to elucidate the mechanisms of DBS therapies in animal models of disease." @default.
• W2898715082 created "2018-11-09" @default.
• W2898715082 creator A5010445034 @default.
• W2898715082 creator A5021959391 @default.
• W2898715082 creator A5023304014 @default.
• W2898715082 creator A5023981328 @default.
• W2898715082 creator A5032688583 @default.
• W2898715082 creator A5033983195 @default.
• W2898715082 creator A5048719476 @default.
• W2898715082 creator A5049719969 @default.
• W2898715082 creator A5049857274 @default.
• W2898715082 creator A5054540792 @default.
• W2898715082 creator A5067159497 @default.
• W2898715082 creator A5074402297 @default.
• W2898715082 creator A5080183379 @default.
• W2898715082 date "2018-11-02" @default.
• W2898715082 modified "2023-09-23" @default.
• W2898715082 title "Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures" @default.
• W2898715082 cites W1596079174 @default.
• W2898715082 cites W1963786511 @default.
• W2898715082 cites W1964696307 @default.
• W2898715082 cites W1966260988 @default.
• W2898715082 cites W1976452441 @default.
• W2898715082 cites W1979370410 @default.
• W2898715082 cites W1993271363 @default.
• W2898715082 cites W1995360097 @default.
• W2898715082 cites W1998123715 @default.
• W2898715082 cites W2000929270 @default.
• W2898715082 cites W2008635511 @default.
• W2898715082 cites W2010541742 @default.
• W2898715082 cites W2016544342 @default.
• W2898715082 cites W2036595429 @default.
• W2898715082 cites W2037608973 @default.
• W2898715082 cites W2042377848 @default.
• W2898715082 cites W2046259291 @default.
• W2898715082 cites W2050426362 @default.
• W2898715082 cites W2052676993 @default.
• W2898715082 cites W2057435588 @default.
• W2898715082 cites W2060890490 @default.
• W2898715082 cites W2062865989 @default.
• W2898715082 cites W2065147517 @default.
• W2898715082 cites W2067452963 @default.
• W2898715082 cites W2082855542 @default.
• W2898715082 cites W2084212509 @default.
• W2898715082 cites W2087599430 @default.
• W2898715082 cites W2087853632 @default.
• W2898715082 cites W2091078081 @default.
• W2898715082 cites W2093883044 @default.
• W2898715082 cites W2094679226 @default.
• W2898715082 cites W2107635023 @default.
• W2898715082 cites W2109713218 @default.
• W2898715082 cites W2111812646 @default.
• W2898715082 cites W2112002552 @default.
• W2898715082 cites W2115857124 @default.
• W2898715082 cites W2119751811 @default.
• W2898715082 cites W2123208606 @default.
• W2898715082 cites W2130424909 @default.
• W2898715082 cites W2132128336 @default.
• W2898715082 cites W2135629133 @default.
• W2898715082 cites W2137011456 @default.
• W2898715082 cites W2139481898 @default.
• W2898715082 cites W2139526581 @default.
• W2898715082 cites W2146291422 @default.
• W2898715082 cites W2153046714 @default.
• W2898715082 cites W2158334924 @default.
• W2898715082 cites W2161248222 @default.
• W2898715082 cites W2231009150 @default.
• W2898715082 cites W2273149779 @default.
• W2898715082 cites W2274452385 @default.
• W2898715082 cites W2397643408 @default.
• W2898715082 cites W2521836369 @default.
• W2898715082 cites W2550961348 @default.
• W2898715082 cites W2560401299 @default.
• W2898715082 cites W2562151313 @default.
• W2898715082 cites W2591607137 @default.
• W2898715082 cites W2616708953 @default.
• W2898715082 cites W2744294942 @default.
• W2898715082 cites W2745258505 @default.
• W2898715082 cites W2765445094 @default.
• W2898715082 cites W2768048575 @default.
• W2898715082 cites W2777987555 @default.
• W2898715082 cites W2793203742 @default.
• W2898715082 cites W2801746582 @default.
• W2898715082 cites W2888381540 @default.
• W2898715082 cites W2893448790 @default.
• W2898715082 cites W2910783431 @default.
• W2898715082 cites W2952986861 @default.
• W2898715082 cites W3104613409 @default.
• W2898715082 cites W316998922 @default.
• W2898715082 cites W4254152649 @default.
• W2898715082 doi "https://doi.org/10.1101/460220" @default.
• W2898715082 hasPublicationYear "2018" @default.
• W2898715082 type Work @default.
• W2898715082 sameAs 2898715082 @default.
• W2898715082 citedByCount "2" @default.
• W2898715082 countsByYear W28987150822020 @default.
• W2898715082 countsByYear W28987150822023 @default.
• W2898715082 crossrefType "posted-content" @default.
• W2898715082 hasAuthorship W2898715082A5010445034 @default.
• W2898715082 hasAuthorship W2898715082A5021959391 @default.

• next