FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898715647> ?p ?o ?g. }

• W2898715647 endingPage "1202" @default.
• W2898715647 startingPage "1202" @default.
• W2898715647 abstract "The development of non-cellularized injectable suspensions of viscous chitosan (CHI) solutions (1.7⁻3.3% (w/w)), filled with cellulose nanofibers (CNF) (0.02⁻0.6% (w/w)) of the type nanofibrillated cellulose, was proposed for viscosupplementation of the intervertebral disc nucleus pulposus tissue. The achievement of CNF/CHI formulations which can gel in situ at the disc injection site constitutes a minimally-invasive approach to restore damaged/degenerated discs. We studied physico-chemical aspects of the sol and gel states of the CNF/CHI formulations, including the rheological behavior in relation to injectability (sol state) and fiber mechanical reinforcement (gel state). CNF-CHI interactions could be evidenced by a double flow behavior due to the relaxation of the CHI polymer chains and those interacting with the CNFs. At high shear rates resembling the injection conditions with needles commonly used in surgical treatments, both the reference CHI viscous solutions and those filled with CNFs exhibited similar rheological behavior. The neutralization of the flowing and weakly acidic CNF/CHI suspensions yielded composite hydrogels in which the nanofibers reinforced the CHI matrix. We performed evaluations in relation to the biomedical application, such as the effect of the intradiscal injection of the CNF/CHI formulation in pig and rabbit spine models on disc biomechanics. We showed that the injectable formulations became hydrogels in situ after intradiscal gelation, due to CHI neutralization occurring in contact with the body fluids. No leakage of the injectate through the injection canal was observed and the gelled formulation restored the disc height and loss of mechanical properties, which is commonly related to disc degeneration." @default.
• W2898715647 created "2018-11-09" @default.
• W2898715647 creator A5005113537 @default.
• W2898715647 creator A5008790682 @default.
• W2898715647 creator A5025941777 @default.
• W2898715647 creator A5036510056 @default.
• W2898715647 creator A5049353987 @default.
• W2898715647 creator A5057354942 @default.
• W2898715647 creator A5062627265 @default.
• W2898715647 creator A5063654999 @default.
• W2898715647 creator A5078308918 @default.
• W2898715647 creator A5086512363 @default.
• W2898715647 date "2018-10-27" @default.
• W2898715647 modified "2023-10-05" @default.
• W2898715647 title "Injectable and Gellable Chitosan Formulations Filled with Cellulose Nanofibers for Intervertebral Disc Tissue Engineering" @default.
• W2898715647 cites W1922742595 @default.
• W2898715647 cites W1927355457 @default.
• W2898715647 cites W1964253821 @default.
• W2898715647 cites W1970167144 @default.
• W2898715647 cites W1974850065 @default.
• W2898715647 cites W1978593181 @default.
• W2898715647 cites W1992432319 @default.
• W2898715647 cites W1994821830 @default.
• W2898715647 cites W1994875630 @default.
• W2898715647 cites W1996144874 @default.
• W2898715647 cites W1999555533 @default.
• W2898715647 cites W2001245625 @default.
• W2898715647 cites W2002367129 @default.
• W2898715647 cites W2003034438 @default.
• W2898715647 cites W2004601925 @default.
• W2898715647 cites W2005305252 @default.
• W2898715647 cites W2007541230 @default.
• W2898715647 cites W2008151211 @default.
• W2898715647 cites W2010701848 @default.
• W2898715647 cites W2020194142 @default.
• W2898715647 cites W2020322655 @default.
• W2898715647 cites W2024212563 @default.
• W2898715647 cites W2024866505 @default.
• W2898715647 cites W2025195660 @default.
• W2898715647 cites W2028554735 @default.
• W2898715647 cites W2031172597 @default.
• W2898715647 cites W2031770498 @default.
• W2898715647 cites W2035554074 @default.
• W2898715647 cites W2043081448 @default.
• W2898715647 cites W2045175268 @default.
• W2898715647 cites W2045250251 @default.
• W2898715647 cites W2048632096 @default.
• W2898715647 cites W2049880242 @default.
• W2898715647 cites W2053460754 @default.
• W2898715647 cites W2059722815 @default.
• W2898715647 cites W2067782051 @default.
• W2898715647 cites W2068659636 @default.
• W2898715647 cites W2069204464 @default.
• W2898715647 cites W2072627563 @default.
• W2898715647 cites W2077127476 @default.
• W2898715647 cites W2079836265 @default.
• W2898715647 cites W2081793377 @default.
• W2898715647 cites W2086317680 @default.
• W2898715647 cites W2088746601 @default.
• W2898715647 cites W2091218781 @default.
• W2898715647 cites W2112179668 @default.
• W2898715647 cites W2114918609 @default.
• W2898715647 cites W2144667456 @default.
• W2898715647 cites W2196105145 @default.
• W2898715647 cites W2280502838 @default.
• W2898715647 cites W2293110276 @default.
• W2898715647 cites W2323309508 @default.
• W2898715647 cites W2326186725 @default.
• W2898715647 cites W2329393513 @default.
• W2898715647 cites W2381720004 @default.
• W2898715647 cites W2466004253 @default.
• W2898715647 cites W2497092364 @default.
• W2898715647 cites W2514170546 @default.
• W2898715647 cites W2607071863 @default.
• W2898715647 cites W2620547165 @default.
• W2898715647 cites W2735090958 @default.
• W2898715647 cites W2763173089 @default.
• W2898715647 cites W2799396764 @default.
• W2898715647 cites W288251652 @default.
• W2898715647 cites W4256076455 @default.
• W2898715647 cites W4293765706 @default.
• W2898715647 cites W4361868163 @default.
• W2898715647 cites W923597483 @default.
• W2898715647 doi "https://doi.org/10.3390/polym10111202" @default.
• W2898715647 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6290636" @default.
• W2898715647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30961127" @default.
• W2898715647 hasPublicationYear "2018" @default.
• W2898715647 type Work @default.
• W2898715647 sameAs 2898715647 @default.
• W2898715647 citedByCount "71" @default.
• W2898715647 countsByYear W28987156472019 @default.
• W2898715647 countsByYear W28987156472020 @default.
• W2898715647 countsByYear W28987156472021 @default.
• W2898715647 countsByYear W28987156472022 @default.
• W2898715647 countsByYear W28987156472023 @default.
• W2898715647 crossrefType "journal-article" @default.
• W2898715647 hasAuthorship W2898715647A5005113537 @default.
• W2898715647 hasAuthorship W2898715647A5008790682 @default.

• next