FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898723593> ?p ?o ?g. }

• W2898723593 endingPage "269" @default.
• W2898723593 startingPage "265" @default.
• W2898723593 abstract "Inactivation of ARID1A and other components of the nuclear SWI/SNF protein complex occurs at very high frequencies in a variety of human malignancies, suggesting a widespread role for the SWI/SNF complex in tumour suppression1. However, the underlying mechanisms remain poorly understood. Here we show that ARID1A-containing SWI/SNF complex (ARID1A-SWI/SNF) operates as an inhibitor of the pro-oncogenic transcriptional coactivators YAP and TAZ2. Using a combination of gain- and loss-of-function approaches in several cellular contexts, we show that YAP/TAZ are necessary to induce the effects of the inactivation of the SWI/SNF complex, such as cell proliferation, acquisition of stem cell-like traits and liver tumorigenesis. We found that YAP/TAZ form a complex with SWI/SNF; this interaction is mediated by ARID1A and is alternative to the association of YAP/TAZ with the DNA-binding platform TEAD. Cellular mechanotransduction regulates the association between ARID1A-SWI/SNF and YAP/TAZ. The inhibitory interaction of ARID1A-SWI/SNF and YAP/TAZ is predominant in cells that experience low mechanical signalling, in which loss of ARID1A rescues the association between YAP/TAZ and TEAD. At high mechanical stress, nuclear F-actin binds to ARID1A-SWI/SNF, thereby preventing the formation of the ARID1A-SWI/SNF-YAP/TAZ complex, in favour of an association between TEAD and YAP/TAZ. We propose that a dual requirement must be met to fully enable the YAP/TAZ responses: promotion of nuclear accumulation of YAP/TAZ, for example, by loss of Hippo signalling, and inhibition of ARID1A-SWI/SNF, which can occur either through genetic inactivation or because of increased cell mechanics. This study offers a molecular framework in which mechanical signals that emerge at the tissue level together with genetic lesions activate YAP/TAZ to induce cell plasticity and tumorigenesis." @default.
• W2898723593 created "2018-11-09" @default.
• W2898723593 creator A5014768771 @default.
• W2898723593 creator A5027726494 @default.
• W2898723593 creator A5033315995 @default.
• W2898723593 creator A5041931496 @default.
• W2898723593 creator A5046301295 @default.
• W2898723593 creator A5048322928 @default.
• W2898723593 creator A5050868374 @default.
• W2898723593 creator A5051274527 @default.
• W2898723593 creator A5051814576 @default.
• W2898723593 creator A5052056821 @default.
• W2898723593 creator A5054568315 @default.
• W2898723593 creator A5056086288 @default.
• W2898723593 creator A5062565921 @default.
• W2898723593 creator A5062640307 @default.
• W2898723593 creator A5085023809 @default.
• W2898723593 creator A5089091347 @default.
• W2898723593 date "2018-10-31" @default.
• W2898723593 modified "2023-10-05" @default.
• W2898723593 title "The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ" @default.
• W2898723593 cites W1866104439 @default.
• W2898723593 cites W1999815561 @default.
• W2898723593 cites W2004468189 @default.
• W2898723593 cites W2005873273 @default.
• W2898723593 cites W2023775321 @default.
• W2898723593 cites W2026993081 @default.
• W2898723593 cites W2027150010 @default.
• W2898723593 cites W2033152875 @default.
• W2898723593 cites W2040430549 @default.
• W2898723593 cites W2042635844 @default.
• W2898723593 cites W2061058076 @default.
• W2898723593 cites W2062261618 @default.
• W2898723593 cites W2063290334 @default.
• W2898723593 cites W2070879574 @default.
• W2898723593 cites W2074075770 @default.
• W2898723593 cites W2075053675 @default.
• W2898723593 cites W2075470041 @default.
• W2898723593 cites W2086046223 @default.
• W2898723593 cites W2093723806 @default.
• W2898723593 cites W2096489607 @default.
• W2898723593 cites W2098692163 @default.
• W2898723593 cites W2106578635 @default.
• W2898723593 cites W2115235864 @default.
• W2898723593 cites W2119855916 @default.
• W2898723593 cites W2124348590 @default.
• W2898723593 cites W2125156743 @default.
• W2898723593 cites W2146337514 @default.
• W2898723593 cites W2148120557 @default.
• W2898723593 cites W2153665127 @default.
• W2898723593 cites W2171729436 @default.
• W2898723593 cites W2426003472 @default.
• W2898723593 cites W2474317928 @default.
• W2898723593 cites W2518767576 @default.
• W2898723593 cites W2539232660 @default.
• W2898723593 cites W2758838459 @default.
• W2898723593 cites W2809358976 @default.
• W2898723593 cites W2884435515 @default.
• W2898723593 doi "https://doi.org/10.1038/s41586-018-0658-1" @default.
• W2898723593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30401838" @default.
• W2898723593 hasPublicationYear "2018" @default.
• W2898723593 type Work @default.
• W2898723593 sameAs 2898723593 @default.
• W2898723593 citedByCount "204" @default.
• W2898723593 countsByYear W28987235932018 @default.
• W2898723593 countsByYear W28987235932019 @default.
• W2898723593 countsByYear W28987235932020 @default.
• W2898723593 countsByYear W28987235932021 @default.
• W2898723593 countsByYear W28987235932022 @default.
• W2898723593 countsByYear W28987235932023 @default.
• W2898723593 crossrefType "journal-article" @default.
• W2898723593 hasAuthorship W2898723593A5014768771 @default.
• W2898723593 hasAuthorship W2898723593A5027726494 @default.
• W2898723593 hasAuthorship W2898723593A5033315995 @default.
• W2898723593 hasAuthorship W2898723593A5041931496 @default.
• W2898723593 hasAuthorship W2898723593A5046301295 @default.
• W2898723593 hasAuthorship W2898723593A5048322928 @default.
• W2898723593 hasAuthorship W2898723593A5050868374 @default.
• W2898723593 hasAuthorship W2898723593A5051274527 @default.
• W2898723593 hasAuthorship W2898723593A5051814576 @default.
• W2898723593 hasAuthorship W2898723593A5052056821 @default.
• W2898723593 hasAuthorship W2898723593A5054568315 @default.
• W2898723593 hasAuthorship W2898723593A5056086288 @default.
• W2898723593 hasAuthorship W2898723593A5062565921 @default.
• W2898723593 hasAuthorship W2898723593A5062640307 @default.
• W2898723593 hasAuthorship W2898723593A5085023809 @default.
• W2898723593 hasAuthorship W2898723593A5089091347 @default.
• W2898723593 hasBestOaLocation W28987235932 @default.
• W2898723593 hasConcept C104317684 @default.
• W2898723593 hasConcept C14519417 @default.
• W2898723593 hasConcept C166941617 @default.
• W2898723593 hasConcept C167227067 @default.
• W2898723593 hasConcept C177450382 @default.
• W2898723593 hasConcept C179185449 @default.
• W2898723593 hasConcept C185592680 @default.
• W2898723593 hasConcept C2781273526 @default.
• W2898723593 hasConcept C501734568 @default.
• W2898723593 hasConcept C54355233 @default.

• next