FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898723770> ?p ?o ?g. }

• W2898723770 endingPage "509.e9" @default.
• W2898723770 startingPage "496" @default.
• W2898723770 abstract "Recursive splicing (RS) starts by defining an RS-exon, which is then spliced to the preceding exon, thus creating a recursive 5' splice site (RS-5ss). Previous studies focused on cryptic RS-exons, and now we find that the exon junction complex (EJC) represses RS of hundreds of annotated, mainly constitutive RS-exons. The core EJC factors, and the peripheral factors PNN and RNPS1, maintain RS-exon inclusion by repressing spliceosomal assembly on RS-5ss. The EJC also blocks 5ss located near exon-exon junctions, thus repressing inclusion of cryptic microexons. The prevalence of annotated RS-exons is high in deuterostomes, while the cryptic RS-exons are more prevalent in Drosophila, where EJC appears less capable of repressing RS. Notably, incomplete repression of RS also contributes to physiological alternative splicing of several human RS-exons. Finally, haploinsufficiency of the EJC factor Magoh in mice is associated with skipping of RS-exons in the brain, with relevance to the microcephaly phenotype and human diseases." @default.
• W2898723770 created "2018-11-09" @default.
• W2898723770 creator A5000512157 @default.
• W2898723770 creator A5018384674 @default.
• W2898723770 creator A5028630355 @default.
• W2898723770 creator A5032741707 @default.
• W2898723770 creator A5041087095 @default.
• W2898723770 creator A5043688982 @default.
• W2898723770 creator A5046893291 @default.
• W2898723770 creator A5056921400 @default.
• W2898723770 creator A5072570376 @default.
• W2898723770 creator A5081437536 @default.
• W2898723770 creator A5090055907 @default.
• W2898723770 date "2018-11-01" @default.
• W2898723770 modified "2023-10-15" @default.
• W2898723770 title "Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing" @default.
• W2898723770 cites W1472557532 @default.
• W2898723770 cites W1488903292 @default.
• W2898723770 cites W1572331556 @default.
• W2898723770 cites W1794962712 @default.
• W2898723770 cites W1971485679 @default.
• W2898723770 cites W1972274936 @default.
• W2898723770 cites W1989930884 @default.
• W2898723770 cites W2013857263 @default.
• W2898723770 cites W2024694407 @default.
• W2898723770 cites W2024957174 @default.
• W2898723770 cites W2034609545 @default.
• W2898723770 cites W2034691490 @default.
• W2898723770 cites W2037576800 @default.
• W2898723770 cites W2047795717 @default.
• W2898723770 cites W2060077330 @default.
• W2898723770 cites W2062118486 @default.
• W2898723770 cites W2062617571 @default.
• W2898723770 cites W2064128480 @default.
• W2898723770 cites W2069192525 @default.
• W2898723770 cites W2089891619 @default.
• W2898723770 cites W2103158128 @default.
• W2898723770 cites W2107128703 @default.
• W2898723770 cites W2117607440 @default.
• W2898723770 cites W2131226388 @default.
• W2898723770 cites W2139480055 @default.
• W2898723770 cites W2147842901 @default.
• W2898723770 cites W2212235774 @default.
• W2898723770 cites W2342788749 @default.
• W2898723770 cites W2415174329 @default.
• W2898723770 cites W2480770645 @default.
• W2898723770 cites W2520773338 @default.
• W2898723770 cites W2577938819 @default.
• W2898723770 cites W2580355118 @default.
• W2898723770 cites W2741697502 @default.
• W2898723770 cites W2797542779 @default.
• W2898723770 cites W2799994822 @default.
• W2898723770 cites W2805469212 @default.
• W2898723770 cites W2898714964 @default.
• W2898723770 cites W808903011 @default.
• W2898723770 doi "https://doi.org/10.1016/j.molcel.2018.09.033" @default.
• W2898723770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6224609" @default.
• W2898723770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30388411" @default.
• W2898723770 hasPublicationYear "2018" @default.
• W2898723770 type Work @default.
• W2898723770 sameAs 2898723770 @default.
• W2898723770 citedByCount "73" @default.
• W2898723770 countsByYear W28987237702018 @default.
• W2898723770 countsByYear W28987237702019 @default.
• W2898723770 countsByYear W28987237702020 @default.
• W2898723770 countsByYear W28987237702021 @default.
• W2898723770 countsByYear W28987237702022 @default.
• W2898723770 countsByYear W28987237702023 @default.
• W2898723770 crossrefType "journal-article" @default.
• W2898723770 hasAuthorship W2898723770A5000512157 @default.
• W2898723770 hasAuthorship W2898723770A5018384674 @default.
• W2898723770 hasAuthorship W2898723770A5028630355 @default.
• W2898723770 hasAuthorship W2898723770A5032741707 @default.
• W2898723770 hasAuthorship W2898723770A5041087095 @default.
• W2898723770 hasAuthorship W2898723770A5043688982 @default.
• W2898723770 hasAuthorship W2898723770A5046893291 @default.
• W2898723770 hasAuthorship W2898723770A5056921400 @default.
• W2898723770 hasAuthorship W2898723770A5072570376 @default.
• W2898723770 hasAuthorship W2898723770A5081437536 @default.
• W2898723770 hasAuthorship W2898723770A5090055907 @default.
• W2898723770 hasBestOaLocation W28987237701 @default.
• W2898723770 hasConcept C104317684 @default.
• W2898723770 hasConcept C127716648 @default.
• W2898723770 hasConcept C194583182 @default.
• W2898723770 hasConcept C2778776201 @default.
• W2898723770 hasConcept C36823959 @default.
• W2898723770 hasConcept C39917842 @default.
• W2898723770 hasConcept C42576000 @default.
• W2898723770 hasConcept C54355233 @default.
• W2898723770 hasConcept C54458228 @default.
• W2898723770 hasConcept C62257209 @default.
• W2898723770 hasConcept C67705224 @default.
• W2898723770 hasConcept C68838962 @default.
• W2898723770 hasConcept C73758832 @default.
• W2898723770 hasConcept C86803240 @default.
• W2898723770 hasConceptScore W2898723770C104317684 @default.
• W2898723770 hasConceptScore W2898723770C127716648 @default.
• W2898723770 hasConceptScore W2898723770C194583182 @default.

• next