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- W2898747713 abstract "Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in USA and Western world. Polyphenolic compounds are present in our daily diet such as vegetable, fruit, onion, and processed food such as red wine, and dark chocolate. Flavonoids, a member of polyphenols and related compounds have significant antioxidant and anti-inflammatory activity, which could vary based on their structures. Recent studies indicated that quercetin; a flavonol reduces the health risks linked with obesity, heart disease, diabetes and high blood pressure. The objective: This study is designed to investigate the effects of quercetin intake and exercise in atherosclerosis. The study compares the effect of intake of quercetin with exercise on atherosclerotic plaque and biomarkers of atherosclerosis. We conducted three separate studies as follows: Study 1: C57BL6 wild type female mice (N=35). Study 2: C57BL6 wild type male mice (N=40) and Study 3: C57BL6 LDLr -/- mice (N=40). Mice were fed normal mouse chow or atherogenic diet and orally supplied with 100 μg/day of quercetin with or without exercising. In each study animals were divided into four groups (10 each). These groups were as follows: Control mice, left untreated; control quercetin group, exercise group without quercetin, and exercise group with quercetin supplements. The exercise groups were run on a treadmill for 30 minutes, 15-30 m/m/ 5 days/week for 30-60 days. At the end of the 1-2 month of treatment, mice were sacrificed. Livers, aortas, adipose tissue and blood were collected. Plasma lipids, and inflammatory biomarkers, and liver and aorta gene expressions and western blot were performed. In wildtype males lipids modulators such as PCSK9 mRNA levels were significantly up-regulated with combination of exercise and quercetin intake (p< 0.05). ANGPLT4 mRNA levels significantly down-regulated with the combination after 8 weeks of exercise and quercetin intake compared to both" @default.
- W2898747713 created "2018-11-09" @default.
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- W2898747713 date "2018-11-01" @default.
- W2898747713 modified "2023-09-24" @default.
- W2898747713 title "Role of polyphenolic flavonoid and exercise in atherosclerosis" @default.
- W2898747713 doi "https://doi.org/10.1016/j.freeradbiomed.2018.10.017" @default.
- W2898747713 hasPublicationYear "2018" @default.
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