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- W2898754529 abstract "Summary Helminth infections leave a long‐lasting immunological footprint on their hosts. Clinical studies have provided first evidence that maternal helminth infections can result in an altered immune profile in their offspring which can potentially shape how they respond to conditions throughout life. This can relate to changes in offspring induction of immune responses against other diseases. However, whether these changes result in actual changes in offspring ability to control disease is unclear. Our understanding of which immune mechanisms are altered and how they are changed is limited. In this review, we highlight what we know from human and mouse studies about this important context of helminth exposure. Moreover, we discuss how mechanisms such as antibody transfer, antigen exposure, maternal cell uptake, chimerism and epigenetics are all likely to be functional contributors to the striking changes that are seen in offspring born or nursed by helminth exposed mothers." @default.
- W2898754529 created "2018-11-09" @default.
- W2898754529 creator A5019840467 @default.
- W2898754529 creator A5041612571 @default.
- W2898754529 creator A5047144665 @default.
- W2898754529 creator A5074102689 @default.
- W2898754529 date "2018-11-20" @default.
- W2898754529 modified "2023-10-18" @default.
- W2898754529 title "Maternal helminth infections and the shaping of offspring immunity" @default.
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