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- W2898759159 abstract "Objectives: A total adrenalectomy of affected adrenal is the standard therapy for aldosterone-producing adenoma (APA), which is a curable subtype of primary aldosteronism (PA). However, there are cases in which total adrenalectomy could not be performed because of bilateral adenomas or incapability of operation under general anesthesia. For these cases, a radiofrequency ablation (RFA) treatment, which is minimally invasive and enables cortical-sparing treatment, could be a choice of treatment. To assess the effectiveness and safety of RFA treatment for APA, a multicenter clinical trial was performed in Japan. Methods: A long-term effect of RFA treatment for APA was monitored and analyzed. Results: Among 10 cases of APA in which RFA treatment was performed between June 2015 and March 2016, there were 8 cases in which biochemical cure was confirmed at the end of the clinical study (84 days after RFA treatment) and follow-up data for at least 1 year were available. Among them, aldosterone-renin ratio (ARR) remained above normal range in 2 cases, while blood pressure and potassium level remained normalized in these cases. Hypertension was not cured in 1 case though ARR reversed to normal in the case. Urinary albumin levels were improved in all cases. Follow-up CT image was available in five cases, showing tumor vanished in 1 case, shrank in 2 cases and unchanged in 2 cases. There were no cases indicating adrenal insufficiency after RFA treatment. Conclusion: In median 2-year follow-up after RFA treatment, there were a few cases in which ARR or blood pressure remained high, however, there were no cases suggesting recurrence. The careful continuous follow-up of these cases is needed." @default.
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- W2898759159 date "2018-10-01" @default.
- W2898759159 modified "2023-09-25" @default.
- W2898759159 title "A15752 Clinical outcomes after radiofrequency ablation treatment for aldosterone-producing adenoma at Keio University Hospital - 2018 annual report -" @default.
- W2898759159 doi "https://doi.org/10.1097/01.hjh.0000548957.93181.e1" @default.
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