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• W2898767543 abstract "INTRODUCTION: Seizures are the most distinctive manifestation of neurologic dysfunctionin the newborn infant. Moreover, neonatal seizures often herald potentiallydevastating forms of brain injury. In earlier reports, seizures occurred in up to 3in 1,000 full-term infants and up to 60 in 1,000 premature infants. However, thereported incidence of neonatal seizures varies widely across studies, avariability that is primarily the result of inconsistent diagnostic criteria, as wellas the often subtle clinical manifestations of neonatal seizures, and theirpotential confusion with non epileptic neonatal behaviors. Regardless of theirprecise incidence, it is clear that seizures are more common in the newbornperiod than at any other time in life, and that the tendency toward recurrentseizures and status epilepticus is far greater in the newborn.Neonatal seizure has an adverse effect on the neurodevelopment of thebaby and may predispose to cognitive, behavioral or epileptic complication laterin life. Hence it is indeed a real emergency to diagnose neonatal seizures asearly as possible and treat it to prevent complications later in life. OBJECTIVES OF THE STUDY: 1. To study the incidence of neonatal seizures.2. To analyze the baseline characteristics like sex, birth weight, gestationalage, intra uterine nutritional status and the mode of deliveries.3. To study the clinical profile of neonatal seizures like etiology, varioustypes, time of onset of seizures and bio chemical abnormalities.4. To study the immediate outcome of neonatal seizures. SUMMARY: 1) Incidence of neonatal seizures was 11.7 / 1000 live births.2) Incidence was more in preterm than term neonates (5.18% Vs 0.58%)3) Neonatal seizures constitute about 4.4% of all NICU admissions, amongwhich preterm more than term (13.3% Vs 2.4%)4) Neonatal seizures showed increased distribution in males than females(57.5% Vs 42.5%) with male to female ratio of 1.4: 1.5) Neonatal seizures were more common in LBW babies (2.9%)6) Neonatal seizures were more common in SGA babies than AGA babies (51.5 % Vs 37.5 %). Of all SGA neonatal seizures were more in pretermthan term (55.9% Vs 41.2%)7) Equal distribution of neonatal seizures in normal vaginal and LSCSdeliveries (1.1%) with higher incidence among breech and forcepsdeliveries (2.6%)8) Incidence of neonatal seizures was more than twice in twins as singletondeliveries (2.4% Vs 1.2%)9) Birth asphyxia (53%) was the most common cause of all neonatalseizures followed by sepsis (33.3%), metabolic abnormalities, intracranial hemorrhage etc.10) Cause remains undetermined in 3.9% of cases 11) Subtle seizures (40.9%) were the commonest type of seizure observedfollowed by multifocal clonic (35.6%)12) Subtle seizures were more common in preterm neonates while multifocalseizures were more common in term neonates.13) Multifocal seizures were 2 times more common in < 24 hrs of life whilesubtle seizures common in 24 – 72 hrs.14) 87.9% of neonatal seizures occurred in <72 hrs with 39.4% in < 24hrs & 48.5% in 24-72 hrs.15) Of the preterm neonates, neonatal seizures were more common in 24 –72 hrs of life while in term neonates more common in < 24 hrs of life.16) 19 neonates (14.4%) died of 132 cases and 113 were discharged fromNICU.17) Mortality was higher in LBW babies than babies of normal birth weight.(21.6% Vs 5.2%)18) Mortality was higher in preterm neonates than term neonates (21.4% Vs7%)19) There was no difference in the outcome of neonatal seizures with intrauterine nutritional status. CONCLUSION: 1. Incidence of neonatal seizures was 11.7 / 1000 live births.2. Neonatal seizures were more common in preterm, LBW and twindeliveries. Also higher among those delivered by breech and forcepsdeliveries.3. 87.9% of neonatal seizures occurred within 72 hours of life.4. Birth asphyxia was the most common cause of all neonatal seizuresfollowed by sepsis.5. Subtle seizures were the commonest type of seizure observed followed bymultifocal clonic.6. Subtle seizures were more common in preterm neonates and in 24 – 72hours of life, while multifocal seizures were more common in termneonates and in < 24 hours of life.7. Mortality was higher in LBW and preterm babies. There was nodifference in the immediate outcome of neonatal seizures with intrauterine nutritional status." @default.
• W2898767543 created "2018-11-09" @default.
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• W2898767543 date "2011-04-01" @default.
• W2898767543 modified "2023-09-27" @default.
• W2898767543 title "Neonatal Seizures: A Comprehensive study" @default.
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