FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898814165> ?p ?o ?g. }

• W2898814165 abstract "Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein (FMRP), an RNA binding protein whose deficiency impacts many brain functions, including differentiation of adult neural stem cells (aNSCs). However, the mechanism by which FMRP influences these processes remains unclear. Here, we performed ribosome profiling and transcriptomic analysis of aNSCs in parallel from wild-type and Fmr1 knockout mice. Our data revealed diverse gene expression changes at both mRNA and translation levels. Many mitosis and neurogenesis genes were dysregulated primarily at the mRNA level, while numerous synaptic genes were mostly dysregulated at the translation level. Translational buffering, whereby changes in ribosome association with mRNA are compensated by alterations in RNA abundance, was also evident. Knockdown of NECDIN, an FMRP-repressed transcriptional factor, rescued neuronal differentiation. In addition, we discovered that FMRP regulates mitochondrial mRNA expression and energy homeostasis. Thus, FMRP controls diverse transcriptional and posttranscriptional gene expression programs critical for neural differentiation." @default.
• W2898814165 created "2018-11-09" @default.
• W2898814165 creator A5001094030 @default.
• W2898814165 creator A5004535291 @default.
• W2898814165 creator A5042061460 @default.
• W2898814165 creator A5044367029 @default.
• W2898814165 creator A5053691210 @default.
• W2898814165 creator A5058102315 @default.
• W2898814165 creator A5074827075 @default.
• W2898814165 creator A5082083166 @default.
• W2898814165 date "2018-10-29" @default.
• W2898814165 modified "2023-09-30" @default.
• W2898814165 title "Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation" @default.
• W2898814165 cites W1955207250 @default.
• W2898814165 cites W1965456948 @default.
• W2898814165 cites W1972726904 @default.
• W2898814165 cites W1976582013 @default.
• W2898814165 cites W1980396381 @default.
• W2898814165 cites W1989212815 @default.
• W2898814165 cites W1994376863 @default.
• W2898814165 cites W2001215117 @default.
• W2898814165 cites W2002378374 @default.
• W2898814165 cites W2024751967 @default.
• W2898814165 cites W2036879857 @default.
• W2898814165 cites W2037313242 @default.
• W2898814165 cites W2050001847 @default.
• W2898814165 cites W2051328227 @default.
• W2898814165 cites W2052326665 @default.
• W2898814165 cites W2079517684 @default.
• W2898814165 cites W2085315897 @default.
• W2898814165 cites W2089927164 @default.
• W2898814165 cites W2096476959 @default.
• W2898814165 cites W2099545905 @default.
• W2898814165 cites W2101635884 @default.
• W2898814165 cites W2102535456 @default.
• W2898814165 cites W2115290127 @default.
• W2898814165 cites W2117391623 @default.
• W2898814165 cites W2120836514 @default.
• W2898814165 cites W2123824748 @default.
• W2898814165 cites W2137790111 @default.
• W2898814165 cites W2140752483 @default.
• W2898814165 cites W2150626351 @default.
• W2898814165 cites W2157742595 @default.
• W2898814165 cites W2167725902 @default.
• W2898814165 cites W2180760460 @default.
• W2898814165 cites W2237226910 @default.
• W2898814165 cites W2306137721 @default.
• W2898814165 cites W2343724650 @default.
• W2898814165 cites W2460957862 @default.
• W2898814165 cites W2560161642 @default.
• W2898814165 cites W2744596343 @default.
• W2898814165 cites W2745668358 @default.
• W2898814165 cites W2752985760 @default.
• W2898814165 cites W2754553258 @default.
• W2898814165 cites W2766811921 @default.
• W2898814165 cites W2786107072 @default.
• W2898814165 cites W2787351196 @default.
• W2898814165 cites W2788138562 @default.
• W2898814165 cites W2797218669 @default.
• W2898814165 cites W2808831647 @default.
• W2898814165 doi "https://doi.org/10.1073/pnas.1809588115" @default.
• W2898814165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6275535" @default.
• W2898814165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30373821" @default.
• W2898814165 hasPublicationYear "2018" @default.
• W2898814165 type Work @default.
• W2898814165 sameAs 2898814165 @default.
• W2898814165 citedByCount "75" @default.
• W2898814165 countsByYear W28988141652018 @default.
• W2898814165 countsByYear W28988141652019 @default.
• W2898814165 countsByYear W28988141652020 @default.
• W2898814165 countsByYear W28988141652021 @default.
• W2898814165 countsByYear W28988141652022 @default.
• W2898814165 countsByYear W28988141652023 @default.
• W2898814165 crossrefType "journal-article" @default.
• W2898814165 hasAuthorship W2898814165A5001094030 @default.
• W2898814165 hasAuthorship W2898814165A5004535291 @default.
• W2898814165 hasAuthorship W2898814165A5042061460 @default.
• W2898814165 hasAuthorship W2898814165A5044367029 @default.
• W2898814165 hasAuthorship W2898814165A5053691210 @default.
• W2898814165 hasAuthorship W2898814165A5058102315 @default.
• W2898814165 hasAuthorship W2898814165A5074827075 @default.
• W2898814165 hasAuthorship W2898814165A5082083166 @default.
• W2898814165 hasBestOaLocation W28988141651 @default.
• W2898814165 hasConcept C104317684 @default.
• W2898814165 hasConcept C105580179 @default.
• W2898814165 hasConcept C136834591 @default.
• W2898814165 hasConcept C149364088 @default.
• W2898814165 hasConcept C150194340 @default.
• W2898814165 hasConcept C162317418 @default.
• W2898814165 hasConcept C165864922 @default.
• W2898814165 hasConcept C173396325 @default.
• W2898814165 hasConcept C182325514 @default.
• W2898814165 hasConcept C2779063550 @default.
• W2898814165 hasConcept C28328180 @default.
• W2898814165 hasConcept C3020422209 @default.
• W2898814165 hasConcept C39685955 @default.
• W2898814165 hasConcept C41282012 @default.
• W2898814165 hasConcept C4746552 @default.
• W2898814165 hasConcept C54355233 @default.
• W2898814165 hasConcept C86803240 @default.

• next