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- W2898814790 endingPage "417" @default.
- W2898814790 startingPage "417" @default.
- W2898814790 abstract "Cone snail venoms provide an ideal resource for neuropharmacological tools and drug candidates discovery, which have become a research hotspot in neuroscience and new drug development. More than 1,000,000 natural peptides are produced by cone snails, but less than 0.1% of the estimated conotoxins has been characterized to date. Hence, the discovery of novel conotoxins from the huge conotoxin resources with high-throughput and sensitive methods becomes a crucial key for the conotoxin-based drug development. In this review, we introduce the discovery methodology of new conotoxins from various Conus species. It focuses on obtaining full N- to C-terminal sequences, regardless of disulfide bond connectivity through crude venom purification, conotoxin precusor gene cloning, venom duct transcriptomics, venom proteomics and multi-omic methods. The protocols, advantages, disadvantages, and developments of different approaches during the last decade are summarized and the promising prospects are discussed as well." @default.
- W2898814790 created "2018-11-09" @default.
- W2898814790 creator A5015971198 @default.
- W2898814790 creator A5021726541 @default.
- W2898814790 creator A5022598327 @default.
- W2898814790 creator A5033151110 @default.
- W2898814790 creator A5040985279 @default.
- W2898814790 date "2018-10-30" @default.
- W2898814790 modified "2023-10-16" @default.
- W2898814790 title "Discovery Methodology of Novel Conotoxins from Conus Species" @default.
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