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• W2898818822 abstract "Abstract Background Nuclear imaging modalities using 123 Iodine-metaiodobenzylguanidine ( 123 I-MIBG) and bone seeking tracers identify early cardiac involvement in ATTRm amyloidosis patients. However, little is known whether results from 123 I-MIBG scintigraphy actually correlate to markers for either cardiac autonomic neuropathy or cardiomyopathy. Methods All TTR mutation carriers and ATTRm patients who underwent both 123 I-MIBG and 99m Technetium-hydroxymethylene diphosphonate ( 99m Tc-HDP) scintigraphy were included. Cardiomyopathy was defined as NT-proBNP > 365 ng/L, and cardiac autonomic neuropathy as abnormal cardiovascular reflexes at autonomic function tests. Late 123 I-MIBG heart-to-mediastinum ratio (HMR) < 2.0 or wash-out > 20%, and any cardiac 99m Tc-HDP uptake were considered as abnormal. Results 39 patients (13 carriers and 26 ATTRm patients) were included in this study. Patients with cardiomyopathy, with or without cardiac autonomic neuropathy, had lower late HMR than similar patients without cardiomyopathy [median 1.1 (range 1.0-1.5) and 1.5(1.2-2.6) vs 2.4 (1.4-3.8) and 2.5 (1.5-3.7), respectively, P < 0.001]. Late HMR and wash-out (inversely) correlated with NT-proBNP r = − 0.652 ( P < 0.001) and r = 0.756 ( P < 0.001), respectively. Furthermore, late HMR and wash-out (inversely) correlated with cardiac 99m Tc-HDP uptake r = − 0.663 ( P < 0.001) and r = 0.617 ( P < 0.001), respectively. Conclusion In case of heart failure, 123 I-MIBG scintigraphy reflects cardiomyopathy rather than cardiac autonomic neuropathy in ATTRm patients and TTR mutation carriers. 123 I-MIBG scintigraphy may already be abnormal before any cardiac bone tracer uptake is visible." @default.
• W2898818822 created "2018-11-09" @default.
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• W2898818822 date "2018-10-29" @default.
• W2898818822 modified "2023-09-26" @default.
• W2898818822 title "Imaging cardiac innervation in hereditary transthyretin (ATTRm) amyloidosis: A marker for neuropathy or cardiomyopathy in case of heart failure?" @default.
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• W2898818822 doi "https://doi.org/10.1007/s12350-018-01477-y" @default.
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