FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898820822> ?p ?o ?g. }

• W2898820822 endingPage "504" @default.
• W2898820822 startingPage "497" @default.
• W2898820822 abstract "Objective: Angiogenesis is one of the key processes in the development of malignant tumors. The vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) signaling pathway regulates branching angiogenesis in cancer. In this study, we analyzed the associations of VEGF/VEGFR-2 proteins and VEGFR-2 genetic variations with the prognosis of gastric cancer (GC).Method: We collected the clinical information of patients with GC and extracted genomic DNA from paraffin-embedded tissues. Immunohistochemical methods were used to detect the expression of VEGF and VEGFR-2 in GC tissues. Four single nucleotide polymorphisms of VEGFR-2 were detected by the TaqMan assay. The Kaplan-Meier method and Cox regression model were applied to analyze the associations between clinicopathological characteristics, VEGFR-2 polymorphisms and GC prognosis.Results: A total of 256 cases of GC were included in our study. VEGFR-2 (+) and VEGFR-2 (++/+++) protein expression levels were detected in 83 and 135 cases, respectively. High expression of the VEGFR-2 protein was associated with the poor prognosis of GC (log-rank test P = 0.026). No statistical significance was observed for the association between VEGF and the prognosis of GC. The VEGFR-2 rs1870377 A > T genetic polymorphism was discovered to be associated with the prognosis of GC (AA vs. AT, HR = 1.69, 95% CI = 1.06–2.68, P = 0.027).Conclusion: Our study suggested that the high expression of VEGFR-2, as well as the VEGFR-2 rs1870377 A > T genetic polymorphism, may be prognostic markers for GC." @default.
• W2898820822 created "2018-11-09" @default.
• W2898820822 creator A5007485276 @default.
• W2898820822 creator A5011785535 @default.
• W2898820822 creator A5045122288 @default.
• W2898820822 creator A5049486408 @default.
• W2898820822 creator A5063029305 @default.
• W2898820822 creator A5076887655 @default.
• W2898820822 creator A5077622749 @default.
• W2898820822 date "2018-10-31" @default.
• W2898820822 modified "2023-10-18" @default.
• W2898820822 title "The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer" @default.
• W2898820822 cites W1818377738 @default.
• W2898820822 cites W1978139448 @default.
• W2898820822 cites W1983763042 @default.
• W2898820822 cites W2007553857 @default.
• W2898820822 cites W2023851673 @default.
• W2898820822 cites W2031389814 @default.
• W2898820822 cites W2037094200 @default.
• W2898820822 cites W2040089666 @default.
• W2898820822 cites W2043025986 @default.
• W2898820822 cites W2053221827 @default.
• W2898820822 cites W2073243152 @default.
• W2898820822 cites W2078966764 @default.
• W2898820822 cites W2081625073 @default.
• W2898820822 cites W2107919129 @default.
• W2898820822 cites W2120384717 @default.
• W2898820822 cites W2127878160 @default.
• W2898820822 cites W2147934804 @default.
• W2898820822 cites W2168685702 @default.
• W2898820822 cites W2349962717 @default.
• W2898820822 cites W2521789051 @default.
• W2898820822 cites W2580449060 @default.
• W2898820822 cites W2917837889 @default.
• W2898820822 doi "https://doi.org/10.1080/15384047.2018.1537575" @default.
• W2898820822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6422475" @default.
• W2898820822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30380970" @default.
• W2898820822 hasPublicationYear "2018" @default.
• W2898820822 type Work @default.
• W2898820822 sameAs 2898820822 @default.
• W2898820822 citedByCount "10" @default.
• W2898820822 countsByYear W28988208222019 @default.
• W2898820822 countsByYear W28988208222021 @default.
• W2898820822 countsByYear W28988208222022 @default.
• W2898820822 countsByYear W28988208222023 @default.
• W2898820822 crossrefType "journal-article" @default.
• W2898820822 hasAuthorship W2898820822A5007485276 @default.
• W2898820822 hasAuthorship W2898820822A5011785535 @default.
• W2898820822 hasAuthorship W2898820822A5045122288 @default.
• W2898820822 hasAuthorship W2898820822A5049486408 @default.
• W2898820822 hasAuthorship W2898820822A5063029305 @default.
• W2898820822 hasAuthorship W2898820822A5076887655 @default.
• W2898820822 hasAuthorship W2898820822A5077622749 @default.
• W2898820822 hasBestOaLocation W28988208221 @default.
• W2898820822 hasConcept C104317684 @default.
• W2898820822 hasConcept C121608353 @default.
• W2898820822 hasConcept C126322002 @default.
• W2898820822 hasConcept C135763542 @default.
• W2898820822 hasConcept C143660080 @default.
• W2898820822 hasConcept C143998085 @default.
• W2898820822 hasConcept C153209595 @default.
• W2898820822 hasConcept C167734588 @default.
• W2898820822 hasConcept C203014093 @default.
• W2898820822 hasConcept C204232928 @default.
• W2898820822 hasConcept C2777025900 @default.
• W2898820822 hasConcept C2780394083 @default.
• W2898820822 hasConcept C48023723 @default.
• W2898820822 hasConcept C502942594 @default.
• W2898820822 hasConcept C54355233 @default.
• W2898820822 hasConcept C71924100 @default.
• W2898820822 hasConcept C86803240 @default.
• W2898820822 hasConceptScore W2898820822C104317684 @default.
• W2898820822 hasConceptScore W2898820822C121608353 @default.
• W2898820822 hasConceptScore W2898820822C126322002 @default.
• W2898820822 hasConceptScore W2898820822C135763542 @default.
• W2898820822 hasConceptScore W2898820822C143660080 @default.
• W2898820822 hasConceptScore W2898820822C143998085 @default.
• W2898820822 hasConceptScore W2898820822C153209595 @default.
• W2898820822 hasConceptScore W2898820822C167734588 @default.
• W2898820822 hasConceptScore W2898820822C203014093 @default.
• W2898820822 hasConceptScore W2898820822C204232928 @default.
• W2898820822 hasConceptScore W2898820822C2777025900 @default.
• W2898820822 hasConceptScore W2898820822C2780394083 @default.
• W2898820822 hasConceptScore W2898820822C48023723 @default.
• W2898820822 hasConceptScore W2898820822C502942594 @default.
• W2898820822 hasConceptScore W2898820822C54355233 @default.
• W2898820822 hasConceptScore W2898820822C71924100 @default.
• W2898820822 hasConceptScore W2898820822C86803240 @default.
• W2898820822 hasIssue "4" @default.
• W2898820822 hasLocation W28988208221 @default.
• W2898820822 hasLocation W28988208222 @default.
• W2898820822 hasLocation W28988208223 @default.
• W2898820822 hasLocation W28988208224 @default.
• W2898820822 hasOpenAccess W2898820822 @default.
• W2898820822 hasPrimaryLocation W28988208221 @default.
• W2898820822 hasRelatedWork W1444397246 @default.
• W2898820822 hasRelatedWork W2004747172 @default.
• W2898820822 hasRelatedWork W2076049271 @default.

• next