Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898821186> ?p ?o ?g. }
- W2898821186 endingPage "38" @default.
- W2898821186 startingPage "29" @default.
- W2898821186 abstract "Thymus praecox subsp. skorpilii var. skorpilii (syn. Thymus praecox subsp. jankae (Celak.) Jalas) is consumed as a Turkish folk medicine for the treatment of spasm, sore throat and shortness of breath, also having strong antioxidant activity and the leaves of the plant have been utilized for the treatment of diabetes as the decoction in Turkey.In the present study, we aimed to investigate the potential mechanism of antidiabetic action of Thymus praecox subsp. skorpilii var. skorpilii methanolic extract (TPSE) on streptozotocin (STZ)/nicotinamide (NA)-induced type 2 diabetic rats.Sprague Dawley rats were randomly divided into four groups; control, diabetes, TPSE (100 mg/kg b.w, p.o.) and metformin group (400 mg/kg b.w, p.o.). Diabetes was established in all groups except control group by 55 mg/kg STZ (i.p.) for once 15 min after 100 mg/kg NA injection. 3 days after STZ/NA injection, treatments were administered for three weeks and then rats were decapitated; tissue and blood samples were obtained for measuring the level of glucose transporters (both GLUTs and sodium glucose co-transporters (SGLTs)), enzymes related to glucose (Hexokinase (HK), phosphoenolpyruvate carboxykinase (PEPCK), α-glucosidase) and lipid metabolism (Acetyl-coenzyme carboxylase (ACC)), AST, ALT, creatinine, insulin, anti-inflammatory (IL-10) and inflammatory (TNF-α, IL-1β, IL-6) cytokines, AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucagon like peptide-1 (GLP-1). Histopathological alterations of the pancreas were examined.After three weeks of treatment, TPSE has exhibited a significant reduction of plasma levels of the proinflammatory cytokines. Besides, TPSE treatment elevated plasma insulin levels and normalized blood glucose levels. Moreover, it improved the values of AMPK in liver and GLP-1 in pancreas. Increased α-glucosidase, PEPCK, GLUT-2 and SGLTs levels with the induction of diabetes considerably lowered with TPSE treatment. Especially on SGLT-2, TPSE achieved a more prominent decrease. After the atrophy in Langerhans islets due to diabetes induction, treatment was found to prevent the damage of islets.Based on the findings presented here, it has been concluded that TPSE has marked antidiabetic effects through various pathways on STZ/NA-induced diabetic rats and it may potentially be used as an effective treatment for type 2 diabetes mellitus (T2DM). Further research on isolation of the bioactive components is underway." @default.
- W2898821186 created "2018-11-09" @default.
- W2898821186 creator A5005025760 @default.
- W2898821186 creator A5008398811 @default.
- W2898821186 creator A5008632253 @default.
- W2898821186 creator A5020701095 @default.
- W2898821186 creator A5024622504 @default.
- W2898821186 creator A5040547641 @default.
- W2898821186 creator A5062915410 @default.
- W2898821186 creator A5079123730 @default.
- W2898821186 date "2019-03-01" @default.
- W2898821186 modified "2023-10-18" @default.
- W2898821186 title "The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic β-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats" @default.
- W2898821186 cites W1572193815 @default.
- W2898821186 cites W1581510118 @default.
- W2898821186 cites W1801115008 @default.
- W2898821186 cites W1963696315 @default.
- W2898821186 cites W1977405708 @default.
- W2898821186 cites W2000956051 @default.
- W2898821186 cites W2003817405 @default.
- W2898821186 cites W2010238890 @default.
- W2898821186 cites W2014658432 @default.
- W2898821186 cites W2017806914 @default.
- W2898821186 cites W2018456235 @default.
- W2898821186 cites W2018703215 @default.
- W2898821186 cites W2019227795 @default.
- W2898821186 cites W2020232369 @default.
- W2898821186 cites W2027545319 @default.
- W2898821186 cites W2031882974 @default.
- W2898821186 cites W2035450066 @default.
- W2898821186 cites W2036085963 @default.
- W2898821186 cites W2047769285 @default.
- W2898821186 cites W2047958176 @default.
- W2898821186 cites W2049909557 @default.
- W2898821186 cites W2053155096 @default.
- W2898821186 cites W2058250308 @default.
- W2898821186 cites W2060371641 @default.
- W2898821186 cites W2067233061 @default.
- W2898821186 cites W2073923431 @default.
- W2898821186 cites W2085936949 @default.
- W2898821186 cites W2087036494 @default.
- W2898821186 cites W2094424564 @default.
- W2898821186 cites W2095231407 @default.
- W2898821186 cites W2100090810 @default.
- W2898821186 cites W2109132990 @default.
- W2898821186 cites W2125760235 @default.
- W2898821186 cites W2129069656 @default.
- W2898821186 cites W2133469996 @default.
- W2898821186 cites W2134626457 @default.
- W2898821186 cites W2135152819 @default.
- W2898821186 cites W2138013119 @default.
- W2898821186 cites W2141228342 @default.
- W2898821186 cites W2144526730 @default.
- W2898821186 cites W2144862658 @default.
- W2898821186 cites W2154734829 @default.
- W2898821186 cites W2155287847 @default.
- W2898821186 cites W2158608859 @default.
- W2898821186 cites W2166129373 @default.
- W2898821186 cites W2169403426 @default.
- W2898821186 cites W2209088499 @default.
- W2898821186 cites W2281101580 @default.
- W2898821186 cites W2581920297 @default.
- W2898821186 cites W2586867315 @default.
- W2898821186 cites W2736390409 @default.
- W2898821186 cites W2762803217 @default.
- W2898821186 doi "https://doi.org/10.1016/j.jep.2018.10.028" @default.
- W2898821186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30399410" @default.
- W2898821186 hasPublicationYear "2019" @default.
- W2898821186 type Work @default.
- W2898821186 sameAs 2898821186 @default.
- W2898821186 citedByCount "27" @default.
- W2898821186 countsByYear W28988211862019 @default.
- W2898821186 countsByYear W28988211862020 @default.
- W2898821186 countsByYear W28988211862021 @default.
- W2898821186 countsByYear W28988211862022 @default.
- W2898821186 countsByYear W28988211862023 @default.
- W2898821186 crossrefType "journal-article" @default.
- W2898821186 hasAuthorship W2898821186A5005025760 @default.
- W2898821186 hasAuthorship W2898821186A5008398811 @default.
- W2898821186 hasAuthorship W2898821186A5008632253 @default.
- W2898821186 hasAuthorship W2898821186A5020701095 @default.
- W2898821186 hasAuthorship W2898821186A5024622504 @default.
- W2898821186 hasAuthorship W2898821186A5040547641 @default.
- W2898821186 hasAuthorship W2898821186A5062915410 @default.
- W2898821186 hasAuthorship W2898821186A5079123730 @default.
- W2898821186 hasConcept C126322002 @default.
- W2898821186 hasConcept C134018914 @default.
- W2898821186 hasConcept C185592680 @default.
- W2898821186 hasConcept C2777391703 @default.
- W2898821186 hasConcept C2779280383 @default.
- W2898821186 hasConcept C2779306644 @default.
- W2898821186 hasConcept C555293320 @default.
- W2898821186 hasConcept C71924100 @default.
- W2898821186 hasConcept C98274493 @default.
- W2898821186 hasConceptScore W2898821186C126322002 @default.
- W2898821186 hasConceptScore W2898821186C134018914 @default.
- W2898821186 hasConceptScore W2898821186C185592680 @default.
- W2898821186 hasConceptScore W2898821186C2777391703 @default.