Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898826594> ?p ?o ?g. }
- W2898826594 abstract "Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy in lung cancer treatment. The effects of combined treatment on non-small cell lung cancer (NSCLC) were investigated using cell viability assays and animal models. The influence of HCQ on lysosomal pH was evaluated by lysosomal sensors and confocal microscopy. The effects of HCQ on the tumour immune microenvironment were analysed by flow cytometry. HCQ elevates the lysosomal pH of cancer cells to inactivate P-gp while increasing drug release from the lysosome into the nucleus. Furthermore, single HCQ therapy inhibits lung cancer by inducing macrophage-modulated anti-tumour CD8+ T cell immunity. Moreover, HCQ could promote the transition of M2 tumour-associated macrophages (TAMs) into M1-like macrophages, leading to CD8+ T cell infiltration into the tumour microenvironment. HCQ exerts anti-NSCLC cells effects by reversing the drug sequestration in lysosomes and enhancing the CD8+ T cell immune response. These findings suggest that HCQ could act as a promising chemo-sensitizer and immune regulator for lung cancer chemotherapy in the clinic." @default.
- W2898826594 created "2018-11-09" @default.
- W2898826594 creator A5001125362 @default.
- W2898826594 creator A5003529898 @default.
- W2898826594 creator A5008544946 @default.
- W2898826594 creator A5014241524 @default.
- W2898826594 creator A5015436826 @default.
- W2898826594 creator A5021233178 @default.
- W2898826594 creator A5022317683 @default.
- W2898826594 creator A5023755501 @default.
- W2898826594 creator A5036833337 @default.
- W2898826594 creator A5039993720 @default.
- W2898826594 creator A5048587530 @default.
- W2898826594 creator A5060220713 @default.
- W2898826594 creator A5070962072 @default.
- W2898826594 creator A5071208846 @default.
- W2898826594 creator A5082760270 @default.
- W2898826594 creator A5088764593 @default.
- W2898826594 date "2018-10-29" @default.
- W2898826594 modified "2023-10-16" @default.
- W2898826594 title "Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages" @default.
- W2898826594 cites W1632859538 @default.
- W2898826594 cites W1772173786 @default.
- W2898826594 cites W1898654834 @default.
- W2898826594 cites W1912428744 @default.
- W2898826594 cites W1960468387 @default.
- W2898826594 cites W1968931590 @default.
- W2898826594 cites W1978172515 @default.
- W2898826594 cites W1980485314 @default.
- W2898826594 cites W1981447488 @default.
- W2898826594 cites W2025381786 @default.
- W2898826594 cites W2026668567 @default.
- W2898826594 cites W2034979953 @default.
- W2898826594 cites W2051929083 @default.
- W2898826594 cites W2061123122 @default.
- W2898826594 cites W2065515174 @default.
- W2898826594 cites W2072693879 @default.
- W2898826594 cites W2077499130 @default.
- W2898826594 cites W2079351077 @default.
- W2898826594 cites W2084838499 @default.
- W2898826594 cites W2086350389 @default.
- W2898826594 cites W2088736593 @default.
- W2898826594 cites W2091496750 @default.
- W2898826594 cites W2091729639 @default.
- W2898826594 cites W2116072674 @default.
- W2898826594 cites W2123318646 @default.
- W2898826594 cites W2132564070 @default.
- W2898826594 cites W2134233670 @default.
- W2898826594 cites W2152462290 @default.
- W2898826594 cites W2160095658 @default.
- W2898826594 cites W2195700687 @default.
- W2898826594 cites W2234063371 @default.
- W2898826594 cites W2236897080 @default.
- W2898826594 cites W2343597033 @default.
- W2898826594 cites W2400013370 @default.
- W2898826594 cites W24149268 @default.
- W2898826594 cites W2415141954 @default.
- W2898826594 cites W2467811750 @default.
- W2898826594 cites W2558608698 @default.
- W2898826594 cites W2581686071 @default.
- W2898826594 cites W2616073112 @default.
- W2898826594 cites W2620588310 @default.
- W2898826594 cites W2625859437 @default.
- W2898826594 cites W2737879468 @default.
- W2898826594 cites W2766181274 @default.
- W2898826594 cites W2783225392 @default.
- W2898826594 cites W2789421415 @default.
- W2898826594 cites W2789423629 @default.
- W2898826594 cites W2791051388 @default.
- W2898826594 cites W2794862639 @default.
- W2898826594 cites W2795561878 @default.
- W2898826594 cites W2796323235 @default.
- W2898826594 cites W2802078831 @default.
- W2898826594 cites W2806673503 @default.
- W2898826594 cites W2916810724 @default.
- W2898826594 cites W2953036362 @default.
- W2898826594 cites W842354779 @default.
- W2898826594 doi "https://doi.org/10.1186/s13046-018-0938-5" @default.
- W2898826594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6206903" @default.
- W2898826594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30373678" @default.
- W2898826594 hasPublicationYear "2018" @default.
- W2898826594 type Work @default.
- W2898826594 sameAs 2898826594 @default.
- W2898826594 citedByCount "73" @default.
- W2898826594 countsByYear W28988265942019 @default.
- W2898826594 countsByYear W28988265942020 @default.
- W2898826594 countsByYear W28988265942021 @default.
- W2898826594 countsByYear W28988265942022 @default.
- W2898826594 countsByYear W28988265942023 @default.
- W2898826594 crossrefType "journal-article" @default.
- W2898826594 hasAuthorship W2898826594A5001125362 @default.
- W2898826594 hasAuthorship W2898826594A5003529898 @default.
- W2898826594 hasAuthorship W2898826594A5008544946 @default.
- W2898826594 hasAuthorship W2898826594A5014241524 @default.
- W2898826594 hasAuthorship W2898826594A5015436826 @default.
- W2898826594 hasAuthorship W2898826594A5021233178 @default.
- W2898826594 hasAuthorship W2898826594A5022317683 @default.
- W2898826594 hasAuthorship W2898826594A5023755501 @default.
- W2898826594 hasAuthorship W2898826594A5036833337 @default.
- W2898826594 hasAuthorship W2898826594A5039993720 @default.