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- W2898830938 startingPage "pdb.emo102301" @default.
- W2898830938 abstract "The success of scientists in revealing biological mechanisms has depended in large part on choosing tractable model systems. In 1997, molecular phylogenetics revealed that two of biology's most tractable models— Caenorhabditis elegans and Drosophila —are much more closely related to each other than had been thought previously. I began to explore whether any of the little-studied members of this branch of the tree of life might serve as a new model for comparative biology that could make use of the rich and ongoing sources of information flowing from C. elegans and Drosophila research. Tardigrades, also known as water bears, make up a phylum of microscopic animals. The tardigrade Hypsibius exemplaris (recently disambiguated from a closely related species, Hypsibius dujardini ) can be maintained in laboratories and has a generation time of <2 wk at room temperature. Stocks of animals can be stored frozen and revived. The animals and their embryos are optically clear, and embryos are laid in groups, with each synchronous clutch of embryos laid in a clear molt. We have developed techniques for laboratory study of this system, including methods for microinjection of animals, immunolocalization, in situ hybridization, RNA interference, transcriptomics, and methods for identifying proteins that mediate tolerance to extreme environments. Here, I review the development of this animal as an emerging model system, as well as recent molecular studies aimed at understanding the evolution of developmental mechanisms that underpin the evolution of animal form and at understanding how biological materials can survive extreme environments." @default.
- W2898830938 created "2018-11-09" @default.
- W2898830938 creator A5090874399 @default.
- W2898830938 date "2018-11-01" @default.
- W2898830938 modified "2023-10-13" @default.
- W2898830938 title "The Emergence of the Tardigrade<i>Hypsibius exemplaris</i>as a Model System" @default.
- W2898830938 cites W1479807229 @default.
- W2898830938 cites W1792730527 @default.
- W2898830938 cites W1964408164 @default.
- W2898830938 cites W1964745114 @default.
- W2898830938 cites W1978950476 @default.
- W2898830938 cites W1993140443 @default.
- W2898830938 cites W1993838585 @default.
- W2898830938 cites W1994896479 @default.
- W2898830938 cites W1998675793 @default.
- W2898830938 cites W2012966503 @default.
- W2898830938 cites W2018599282 @default.
- W2898830938 cites W2018964970 @default.
- W2898830938 cites W2019706321 @default.
- W2898830938 cites W2026644379 @default.
- W2898830938 cites W2027730766 @default.
- W2898830938 cites W2029482176 @default.
- W2898830938 cites W2041868620 @default.
- W2898830938 cites W2051953808 @default.
- W2898830938 cites W2084822911 @default.
- W2898830938 cites W2085056220 @default.
- W2898830938 cites W2099487859 @default.
- W2898830938 cites W2102446397 @default.
- W2898830938 cites W2113186749 @default.
- W2898830938 cites W2134681478 @default.
- W2898830938 cites W2137155904 @default.
- W2898830938 cites W2142733645 @default.
- W2898830938 cites W2148533374 @default.
- W2898830938 cites W2151811187 @default.
- W2898830938 cites W2152422523 @default.
- W2898830938 cites W2157430595 @default.
- W2898830938 cites W2160011794 @default.
- W2898830938 cites W2163270621 @default.
- W2898830938 cites W2163940607 @default.
- W2898830938 cites W2165511961 @default.
- W2898830938 cites W2169151423 @default.
- W2898830938 cites W2170341580 @default.
- W2898830938 cites W2178845774 @default.
- W2898830938 cites W2219208709 @default.
- W2898830938 cites W2255506873 @default.
- W2898830938 cites W2267401506 @default.
- W2898830938 cites W2283570988 @default.
- W2898830938 cites W2288824275 @default.
- W2898830938 cites W2306772473 @default.
- W2898830938 cites W2372353813 @default.
- W2898830938 cites W2388307489 @default.
- W2898830938 cites W2437865583 @default.
- W2898830938 cites W2519000269 @default.
- W2898830938 cites W2519471626 @default.
- W2898830938 cites W2523589472 @default.
- W2898830938 cites W2547342446 @default.
- W2898830938 cites W2550894833 @default.
- W2898830938 cites W2550983049 @default.
- W2898830938 cites W2552756124 @default.
- W2898830938 cites W2553529811 @default.
- W2898830938 cites W2554164003 @default.
- W2898830938 cites W2555253418 @default.
- W2898830938 cites W2555307906 @default.
- W2898830938 cites W2572777905 @default.
- W2898830938 cites W2586737773 @default.
- W2898830938 cites W2596822322 @default.
- W2898830938 cites W2614040182 @default.
- W2898830938 cites W2747224316 @default.
- W2898830938 cites W2751552732 @default.
- W2898830938 cites W2753500452 @default.
- W2898830938 cites W2790654278 @default.
- W2898830938 cites W2791301758 @default.
- W2898830938 cites W2800689372 @default.
- W2898830938 cites W2801892591 @default.
- W2898830938 cites W2884797488 @default.
- W2898830938 cites W2898618825 @default.
- W2898830938 cites W2898749072 @default.
- W2898830938 cites W2898947644 @default.
- W2898830938 cites W2899001032 @default.
- W2898830938 cites W2899246523 @default.
- W2898830938 cites W2899274547 @default.
- W2898830938 cites W2899368653 @default.
- W2898830938 cites W2899441110 @default.
- W2898830938 cites W2949529419 @default.
- W2898830938 cites W2950218595 @default.
- W2898830938 cites W3021050504 @default.
- W2898830938 cites W4246944078 @default.
- W2898830938 cites W991105592 @default.
- W2898830938 doi "https://doi.org/10.1101/pdb.emo102301" @default.
- W2898830938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30385668" @default.
- W2898830938 hasPublicationYear "2018" @default.
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