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• W2898832008 abstract "Antibiotics with novel mechanisms of action are desperately needed to combat the increasing rates of multidrug-resistant infections. Bacterial pantothenate kinase (PanK) has emerged as a target of interest to cut off the biosynthesis of coenzyme A. Herein we report the results of an in vitro high-throughput screen of over 10 000 small molecules against Bacillus anthracis PanK, as well as a follow-up screen of hits against PanK isolated from Pseudomonas aeruginosa and Burkholderia cenocepacia. Nine hits are structurally categorized and analyzed to set the stage for future drug development." @default.
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• W2898832008 date "2018-12-03" @default.
• W2898832008 modified "2023-10-14" @default.
• W2898832008 title "Identification of Specific and Nonspecific Inhibitors of <i>Bacillus anthracis</i> Type III Pantothenate Kinase (PanK)" @default.
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• W2898832008 doi "https://doi.org/10.1002/cmdc.201800652" @default.
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