Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898832471> ?p ?o ?g. }
- W2898832471 endingPage "434" @default.
- W2898832471 startingPage "429" @default.
- W2898832471 abstract "Pharmacotherapies for fibromyalgia treatment are lacking. This study examined the antinociceptive and antidepressant-like effects of imidazoline I2 receptor (I2R) agonists in a reserpine-induced model of fibromyalgia in rats. Rats were treated for 3 days with vehicle or reserpine. The von Frey filament test was used to assess the antinociceptive effects of I2 receptor agonists, and the forced swim test was used to assess the antidepressant-like effects of these drugs. 2-BFI (3.2-10 mg/kg, intraperitoneally), phenyzoline (17.8-56 mg/kg, intraperitoneally), and CR4056 (3.2-10 mg/kg, intraperitoneally) all dose-dependently produced significant antinociceptive effects, which were attenuated by the I2R antagonist idazoxan. Only CR4056 significantly reduced the immobility time in the forced swim test in both vehicle-treated and reserpine-treated rats. These data suggest that I2R agonists may be useful to treat fibromyalgia-related pain and comorbid depression." @default.
- W2898832471 created "2018-11-09" @default.
- W2898832471 creator A5007550740 @default.
- W2898832471 creator A5042973851 @default.
- W2898832471 creator A5053506930 @default.
- W2898832471 creator A5056598643 @default.
- W2898832471 creator A5060955235 @default.
- W2898832471 creator A5085140951 @default.
- W2898832471 date "2019-08-01" @default.
- W2898832471 modified "2023-10-12" @default.
- W2898832471 title "Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats" @default.
- W2898832471 cites W1481010882 @default.
- W2898832471 cites W1521322897 @default.
- W2898832471 cites W1526283333 @default.
- W2898832471 cites W1543082199 @default.
- W2898832471 cites W1602034086 @default.
- W2898832471 cites W1604643098 @default.
- W2898832471 cites W1901117276 @default.
- W2898832471 cites W1965796163 @default.
- W2898832471 cites W1978053355 @default.
- W2898832471 cites W1988237909 @default.
- W2898832471 cites W1988347806 @default.
- W2898832471 cites W1988568604 @default.
- W2898832471 cites W1989133401 @default.
- W2898832471 cites W1990590339 @default.
- W2898832471 cites W2000028213 @default.
- W2898832471 cites W2009928888 @default.
- W2898832471 cites W2011487877 @default.
- W2898832471 cites W2017366764 @default.
- W2898832471 cites W2032055370 @default.
- W2898832471 cites W2037818212 @default.
- W2898832471 cites W2051250857 @default.
- W2898832471 cites W2054632071 @default.
- W2898832471 cites W2057615993 @default.
- W2898832471 cites W2061434894 @default.
- W2898832471 cites W206618267 @default.
- W2898832471 cites W2066612487 @default.
- W2898832471 cites W2073363988 @default.
- W2898832471 cites W2074216430 @default.
- W2898832471 cites W2082215577 @default.
- W2898832471 cites W2089299823 @default.
- W2898832471 cites W2091064555 @default.
- W2898832471 cites W2096232673 @default.
- W2898832471 cites W2106059433 @default.
- W2898832471 cites W2109971948 @default.
- W2898832471 cites W2111595594 @default.
- W2898832471 cites W2128868935 @default.
- W2898832471 cites W2144286905 @default.
- W2898832471 cites W2154941518 @default.
- W2898832471 cites W2163703742 @default.
- W2898832471 cites W2169447022 @default.
- W2898832471 cites W2171524367 @default.
- W2898832471 cites W2196196364 @default.
- W2898832471 cites W2278984214 @default.
- W2898832471 cites W2281209287 @default.
- W2898832471 cites W2289941121 @default.
- W2898832471 cites W2320278463 @default.
- W2898832471 cites W2415752306 @default.
- W2898832471 cites W2595647051 @default.
- W2898832471 cites W2791019877 @default.
- W2898832471 cites W2972360543 @default.
- W2898832471 cites W3169575844 @default.
- W2898832471 cites W627231601 @default.
- W2898832471 cites W7637387 @default.
- W2898832471 doi "https://doi.org/10.1097/fbp.0000000000000454" @default.
- W2898832471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6494737" @default.
- W2898832471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30383551" @default.
- W2898832471 hasPublicationYear "2019" @default.
- W2898832471 type Work @default.
- W2898832471 sameAs 2898832471 @default.
- W2898832471 citedByCount "9" @default.
- W2898832471 countsByYear W28988324712020 @default.
- W2898832471 countsByYear W28988324712021 @default.
- W2898832471 countsByYear W28988324712022 @default.
- W2898832471 countsByYear W28988324712023 @default.
- W2898832471 crossrefType "journal-article" @default.
- W2898832471 hasAuthorship W2898832471A5007550740 @default.
- W2898832471 hasAuthorship W2898832471A5042973851 @default.
- W2898832471 hasAuthorship W2898832471A5053506930 @default.
- W2898832471 hasAuthorship W2898832471A5056598643 @default.
- W2898832471 hasAuthorship W2898832471A5060955235 @default.
- W2898832471 hasAuthorship W2898832471A5085140951 @default.
- W2898832471 hasBestOaLocation W28988324712 @default.
- W2898832471 hasConcept C123605464 @default.
- W2898832471 hasConcept C126322002 @default.
- W2898832471 hasConcept C134018914 @default.
- W2898832471 hasConcept C136569192 @default.
- W2898832471 hasConcept C15490471 @default.
- W2898832471 hasConcept C170493617 @default.
- W2898832471 hasConcept C2776885963 @default.
- W2898832471 hasConcept C2777831278 @default.
- W2898832471 hasConcept C2777842393 @default.
- W2898832471 hasConcept C2779177272 @default.
- W2898832471 hasConcept C2779245659 @default.
- W2898832471 hasConcept C2780648677 @default.
- W2898832471 hasConcept C2780939551 @default.
- W2898832471 hasConcept C2781001258 @default.
- W2898832471 hasConcept C2781161787 @default.