FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898834537> ?p ?o ?g. }

• W2898834537 endingPage "5217" @default.
• W2898834537 startingPage "5217" @default.
• W2898834537 abstract "Purpose: To evaluate spontaneous and evoked ocular sensory responses in rats after denervation of the lacrimal gland, as well as protein changes in tears that may mediate functional changes. Methods: Sprague-Dawley rats served as subjects. The left lacrimal gland was partially denervated with saporin toxin conjugated to p75. Unilateral and bilateral eye closures (winks and blinks) and grooming behaviors were measured weekly. Nociceptive responses were evoked by ocular application of menthol; tear production was assessed using the phenol thread test. Relative changes in tear protein abundances were measured using a Tandem Mass Tagging approach. Results: Denervation of the lacrimal gland reduced eye closure behavior, particularly in the ipsilateral eye, and eye wipe responses to noxious menthol were also reduced. Tear volume did not change, but tear protein composition was altered. Proteins implicated in the structural integrity of epithelial cells and in protective functions were reduced by lacrimal denervation, including keratins, serotransferrin, and beta-defensin. Other proteins that may modulate TRPM8 channels and alter sensory neuronal function were reduced, including arachidonate 15-lipoxygenase B. A low-abundance protein that responds to oxidative stress and injury, proteasome subunit beta type 10, was upregulated in denervated rats. Conclusions: Denervation of the lacrimal gland causes long-lasting hypoalgesia, impairs the blink response, and alters tear proteins. Tear proteins were altered without changing tear volume. We speculate that impaired TRPM8 function in corneal sensory nerves may contribute to ocular hypoalgesia, supporting growing evidence that this transduction molecule is important for both nociceptive and spontaneous blinking behaviors." @default.
• W2898834537 created "2018-11-09" @default.
• W2898834537 creator A5029591441 @default.
• W2898834537 creator A5053650946 @default.
• W2898834537 creator A5075056690 @default.
• W2898834537 date "2018-10-25" @default.
• W2898834537 modified "2023-09-24" @default.
• W2898834537 title "Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception" @default.
• W2898834537 cites W1512191088 @default.
• W2898834537 cites W1572223735 @default.
• W2898834537 cites W1574492549 @default.
• W2898834537 cites W1590709895 @default.
• W2898834537 cites W1963051938 @default.
• W2898834537 cites W1968107853 @default.
• W2898834537 cites W1973513527 @default.
• W2898834537 cites W1981536301 @default.
• W2898834537 cites W1994521493 @default.
• W2898834537 cites W1995642991 @default.
• W2898834537 cites W1997101488 @default.
• W2898834537 cites W1997182705 @default.
• W2898834537 cites W1997504014 @default.
• W2898834537 cites W2007527685 @default.
• W2898834537 cites W2019241754 @default.
• W2898834537 cites W2020821598 @default.
• W2898834537 cites W2022429405 @default.
• W2898834537 cites W2026625183 @default.
• W2898834537 cites W2028705982 @default.
• W2898834537 cites W2028828795 @default.
• W2898834537 cites W2033664528 @default.
• W2898834537 cites W2042794878 @default.
• W2898834537 cites W2049377668 @default.
• W2898834537 cites W2053570640 @default.
• W2898834537 cites W2053943711 @default.
• W2898834537 cites W2054679907 @default.
• W2898834537 cites W2055277661 @default.
• W2898834537 cites W2066907652 @default.
• W2898834537 cites W2068181169 @default.
• W2898834537 cites W2070586076 @default.
• W2898834537 cites W2093122630 @default.
• W2898834537 cites W2096357260 @default.
• W2898834537 cites W2106225286 @default.
• W2898834537 cites W2107018762 @default.
• W2898834537 cites W2107057154 @default.
• W2898834537 cites W2113037889 @default.
• W2898834537 cites W2114104545 @default.
• W2898834537 cites W2133335487 @default.
• W2898834537 cites W2150205603 @default.
• W2898834537 cites W2154882048 @default.
• W2898834537 cites W2162385482 @default.
• W2898834537 cites W2169980429 @default.
• W2898834537 cites W2205794177 @default.
• W2898834537 cites W2416076068 @default.
• W2898834537 cites W2586319132 @default.
• W2898834537 cites W2588897146 @default.
• W2898834537 cites W2601488696 @default.
• W2898834537 cites W2950301126 @default.
• W2898834537 cites W297311091 @default.
• W2898834537 cites W85985731 @default.
• W2898834537 doi "https://doi.org/10.1167/iovs.18-25267" @default.
• W2898834537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203219" @default.
• W2898834537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30372750" @default.
• W2898834537 hasPublicationYear "2018" @default.
• W2898834537 type Work @default.
• W2898834537 sameAs 2898834537 @default.
• W2898834537 citedByCount "10" @default.
• W2898834537 countsByYear W28988345372020 @default.
• W2898834537 countsByYear W28988345372021 @default.
• W2898834537 countsByYear W28988345372022 @default.
• W2898834537 crossrefType "journal-article" @default.
• W2898834537 hasAuthorship W2898834537A5029591441 @default.
• W2898834537 hasAuthorship W2898834537A5053650946 @default.
• W2898834537 hasAuthorship W2898834537A5075056690 @default.
• W2898834537 hasBestOaLocation W28988345371 @default.
• W2898834537 hasConcept C126322002 @default.
• W2898834537 hasConcept C134018914 @default.
• W2898834537 hasConcept C142724271 @default.
• W2898834537 hasConcept C15490471 @default.
• W2898834537 hasConcept C169760540 @default.
• W2898834537 hasConcept C170493617 @default.
• W2898834537 hasConcept C2776805190 @default.
• W2898834537 hasConcept C2779298748 @default.
• W2898834537 hasConcept C71924100 @default.
• W2898834537 hasConcept C86803240 @default.
• W2898834537 hasConcept C94487597 @default.
• W2898834537 hasConceptScore W2898834537C126322002 @default.
• W2898834537 hasConceptScore W2898834537C134018914 @default.
• W2898834537 hasConceptScore W2898834537C142724271 @default.
• W2898834537 hasConceptScore W2898834537C15490471 @default.
• W2898834537 hasConceptScore W2898834537C169760540 @default.
• W2898834537 hasConceptScore W2898834537C170493617 @default.
• W2898834537 hasConceptScore W2898834537C2776805190 @default.
• W2898834537 hasConceptScore W2898834537C2779298748 @default.
• W2898834537 hasConceptScore W2898834537C71924100 @default.
• W2898834537 hasConceptScore W2898834537C86803240 @default.
• W2898834537 hasConceptScore W2898834537C94487597 @default.
• W2898834537 hasIssue "12" @default.
• W2898834537 hasLocation W28988345371 @default.
• W2898834537 hasLocation W28988345372 @default.

• next