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- W2898837652 abstract "Radiation therapy (RT) is one of the major treatment for prostate cancer (PCa) and diabetics develop more side effects associated with RT and higher mortality compared to non-diabetics. It is well established that diabetics are under systemic oxidative stress. Reactive oxygen species (ROS) are induced by hyperglycemia mainly through mitochondrial respiratory chain enzymes, and NADPH oxidases (NOX enzymes). Our lab has shown that a manganese porphyrin, MnTE-2-PyP (MnP), prevents radiation-mediated fibrosis by scavenging ROS. Thus, we hypothesize that diabetics are more prone to irradiation damage due to elevated levels of ROS following radiation and that preventing ROS production through the addition of MnP would greatly protect diabetics undergoing RT. In agreement with this hypothesis, the addition of high glucose (20 mM, HG) and radiation (3 Gy, RAD,) significantly enhanced human prostate fibroblast cell death as compared to controls (2.6 fold, p" @default.
- W2898837652 created "2018-11-09" @default.
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- W2898837652 date "2018-11-01" @default.
- W2898837652 modified "2023-09-25" @default.
- W2898837652 title "Protective role of manganese porphyrin against radiation-induced damage in a diabetic environment" @default.
- W2898837652 doi "https://doi.org/10.1016/j.freeradbiomed.2018.10.184" @default.
- W2898837652 hasPublicationYear "2018" @default.
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