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• W2898841311 abstract "Purpose Owing to its noninvasive nature, hyperpolarized MRI may improve delineation of myocardial metabolic derangement in heart disease. However, consistency may depend on the changeable nature of cardiac metabolism in relation to whole‐body metabolic state. This study investigates the impact of feeding status on cardiac hyperpolarized MRI in a large animal model resembling human physiology. Methods Thirteen 30‐kg pigs were subjected to an overnight fast, and 5 pigs were fed a carbohydrate‐rich meal on the morning of the experiments. Vital parameters and blood samples were registered. All pigs were then scanned by hyperpolarized [1‐ 13 C]pyruvate cardiac MRI, and results were compared between the 2 groups and correlated with circulating substrates and hormones. Results The fed group had higher blood glucose concentration and mean arterial pressure than the fasted group. Plasma concentrations of free fatty acids (FFAs) were decreased in the fed group, whereas plasma insulin concentrations were similar between groups. Hyperpolarized MRI showed that fed animals had increased lactate/pyruvate, alanine/pyruvate, and bicarbonate/pyruvate ratios. Metabolic ratios correlated negatively with FFA levels. Conclusion Hyperpolarized MR can identify the effects of different metabolic states on cardiac metabolism in a large animal model. Unlike previous rodent studies, all metabolic derivatives of pyruvate increased in the myocardium of fed pigs. Carbohydrate‐rich feeding seems to be a feasible model for standardized, large animal hyperpolarized MRI studies of myocardial carbohydrate metabolism." @default.
• W2898841311 created "2018-11-09" @default.
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• W2898841311 date "2018-11-02" @default.
• W2898841311 modified "2023-09-30" @default.
• W2898841311 title "Hyperpolarized [1‐ ¹³ C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model" @default.
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• W2898841311 doi "https://doi.org/10.1002/mrm.27560" @default.
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