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- W2898842913 abstract "The small resistance arteries are where the peripheral resistance component of blood pressure regulation occurs. We have previously discovered in endothelial cells of small arteries that alpha hemoglobin, but not beta hemoglobin, is present. This is potentially important as globins in general, and alpha hemoglobin in particular, are potent scavengers of nitric oxide. In order to test for a functional role of alpha hemoglobin in blood pressure regulation and possible nitric oxide interaction, we have developed a tool kit of reagents and model organisms, including a floxed alpha hemoglobin mouse (Hba1fl/fl) and mice with mutated alpha hemoglobin to lack an eNOS binding domain (Hba1M6-39). Using data derived from these tools, I will demonstrate how alpha hemoglobin is an essential component to development of the arterial structure/function relationship to regulate vasodilation. In addition, using data derived from human biopsies and volunteers, I will also discuss how alpha hemoglobin in endothelium may be a potent pharmacological target in hypertensive states." @default.
- W2898842913 created "2018-11-09" @default.
- W2898842913 creator A5036017969 @default.
- W2898842913 date "2018-11-01" @default.
- W2898842913 modified "2023-10-14" @default.
- W2898842913 title "Alpha Hemoglobin in Blood Pressure Regulation" @default.
- W2898842913 doi "https://doi.org/10.1016/j.freeradbiomed.2018.10.375" @default.
- W2898842913 hasPublicationYear "2018" @default.
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