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- W2898843516 abstract "Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia associated with the presence of persistent antiphospholipid antibodies (aPL). Owing to recent studies, not only APS patients but also incidentally-identified, asymptomatic aPL carriers are able to be stratified in terms of the risk of future thrombotic events, according to the variety and the titer of positive aPL tests and to the non-thrombotic, aPL-associated clinical manifestations. Areas covered: Here, we critically review (1) criteria manifestations of APS, (2) non-criteria manifestations of APS, (3) risk assessment in patients with APS and in aPL carriers, and (4) the potential role of primary thrombosis prophylaxis in aPL carriers. In addition, we discuss what we are currently able to do and what we need to do in the future for primary prophylaxis against a first thrombotic event. Expert commentary: We suggest a comprehensive algorithm to stratify thrombotic risk in aPL carriers, including criteria aPL, non-criteria aPL, their scoring systems, and non-criteria manifestations. However, further studies, particularly prospective randomized controlled trials, are highly warranted to establish an effective and tolerable treatment regimen for high risk aPL carriers." @default.
- W2898843516 created "2018-11-09" @default.
- W2898843516 creator A5066941256 @default.
- W2898843516 creator A5070300954 @default.
- W2898843516 creator A5079071350 @default.
- W2898843516 date "2018-11-13" @default.
- W2898843516 modified "2023-09-26" @default.
- W2898843516 title "Clinical profiles and risk assessment in patients with antiphospholipid antibodies" @default.
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- W2898843516 doi "https://doi.org/10.1080/1744666x.2019.1543025" @default.
- W2898843516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30381978" @default.
- W2898843516 hasPublicationYear "2018" @default.
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