FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898845627> ?p ?o ?g. }

• W2898845627 endingPage "648" @default.
• W2898845627 startingPage "642" @default.
• W2898845627 abstract "Purpose of review The aim of this study was to review the recent progress in xenotransplantation achieved through genetic engineering and discuss the potential of tolerance induction to overcome remaining barriers to extended xenograft survival. Recent findings The success of life-saving allotransplantation has created a demand for organ transplantation that cannot be met by the supply of human organs. Xenotransplantation is one possible solution that would allow for a nearly unlimited supply of organs. Recent genetic engineering of swine has decreased the reactivity of preformed antibodies to some, but not all, potential human recipients. Experiments using genetically modified swine organs have now resulted in survival of life-supporting kidneys for over a year. However, the grafts show evidence of antibody-mediated rejection on histology, suggesting additional measures will be required for further extension of graft survival. Tolerance induction through mixed chimerism or thymic transplantation across xenogeneic barriers would be well suited for patients with a positive crossmatch to genetically modified swine or relatively negative crossmatches to genetically modified swine, respectively. Summary This review highlights the current understanding of the immunologic processes in xenotransplantation and describes the development and application of strategies designed to overcome them from the genetic modification of the source animal to the induction of tolerance to xenografts." @default.
• W2898845627 created "2018-11-09" @default.
• W2898845627 creator A5003679165 @default.
• W2898845627 creator A5021758948 @default.
• W2898845627 creator A5056437755 @default.
• W2898845627 date "2018-12-01" @default.
• W2898845627 modified "2023-09-26" @default.
• W2898845627 title "Xenotransplantation tolerance: applications for recent advances in modified swine" @default.
• W2898845627 cites W1488262187 @default.
• W2898845627 cites W1496757932 @default.
• W2898845627 cites W1548258432 @default.
• W2898845627 cites W1618744733 @default.
• W2898845627 cites W1763505703 @default.
• W2898845627 cites W1784712436 @default.
• W2898845627 cites W1965348160 @default.
• W2898845627 cites W1966545572 @default.
• W2898845627 cites W1968616022 @default.
• W2898845627 cites W1971576908 @default.
• W2898845627 cites W1971670067 @default.
• W2898845627 cites W1972357761 @default.
• W2898845627 cites W1972748634 @default.
• W2898845627 cites W1975878181 @default.
• W2898845627 cites W1976060246 @default.
• W2898845627 cites W1978195956 @default.
• W2898845627 cites W1981547271 @default.
• W2898845627 cites W1985886898 @default.
• W2898845627 cites W1990903678 @default.
• W2898845627 cites W1997110147 @default.
• W2898845627 cites W1997152543 @default.
• W2898845627 cites W2000127829 @default.
• W2898845627 cites W2001904337 @default.
• W2898845627 cites W2004234568 @default.
• W2898845627 cites W2012187745 @default.
• W2898845627 cites W2013571030 @default.
• W2898845627 cites W2016481701 @default.
• W2898845627 cites W2019891966 @default.
• W2898845627 cites W2021396106 @default.
• W2898845627 cites W2027284410 @default.
• W2898845627 cites W2027858287 @default.
• W2898845627 cites W2038056757 @default.
• W2898845627 cites W2039521889 @default.
• W2898845627 cites W2044644395 @default.
• W2898845627 cites W2045422704 @default.
• W2898845627 cites W2049862237 @default.
• W2898845627 cites W2051546362 @default.
• W2898845627 cites W2054339804 @default.
• W2898845627 cites W2055343935 @default.
• W2898845627 cites W2060261771 @default.
• W2898845627 cites W2060423622 @default.
• W2898845627 cites W2062400245 @default.
• W2898845627 cites W2062964758 @default.
• W2898845627 cites W2066629734 @default.
• W2898845627 cites W2068128688 @default.
• W2898845627 cites W2069934759 @default.
• W2898845627 cites W2070792507 @default.
• W2898845627 cites W2072137409 @default.
• W2898845627 cites W2081274792 @default.
• W2898845627 cites W2085878243 @default.
• W2898845627 cites W2086243836 @default.
• W2898845627 cites W2090450058 @default.
• W2898845627 cites W2096773027 @default.
• W2898845627 cites W2097197993 @default.
• W2898845627 cites W2105432576 @default.
• W2898845627 cites W2114814098 @default.
• W2898845627 cites W2115629285 @default.
• W2898845627 cites W2122267692 @default.
• W2898845627 cites W2137151166 @default.
• W2898845627 cites W2138099499 @default.
• W2898845627 cites W2138868414 @default.
• W2898845627 cites W2140857511 @default.
• W2898845627 cites W2145051316 @default.
• W2898845627 cites W2146092834 @default.
• W2898845627 cites W2150841203 @default.
• W2898845627 cites W2154468958 @default.
• W2898845627 cites W2163649189 @default.
• W2898845627 cites W2170131604 @default.
• W2898845627 cites W2280520978 @default.
• W2898845627 cites W2314256911 @default.
• W2898845627 cites W2397335844 @default.
• W2898845627 cites W2404891764 @default.
• W2898845627 cites W2416997090 @default.
• W2898845627 cites W2557178154 @default.
• W2898845627 cites W2557775641 @default.
• W2898845627 cites W2575274634 @default.
• W2898845627 cites W2740266422 @default.
• W2898845627 cites W2759820116 @default.
• W2898845627 cites W2804163185 @default.
• W2898845627 cites W2809088558 @default.
• W2898845627 cites W2883354828 @default.
• W2898845627 cites W2884293145 @default.
• W2898845627 cites W4246274882 @default.
• W2898845627 cites W4255862896 @default.
• W2898845627 doi "https://doi.org/10.1097/mot.0000000000000585" @default.
• W2898845627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7010353" @default.
• W2898845627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30379724" @default.
• W2898845627 hasPublicationYear "2018" @default.
• W2898845627 type Work @default.
• W2898845627 sameAs 2898845627 @default.

• next