FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898846475> ?p ?o ?g. }

• W2898846475 abstract "Chaperone-assisted selective autophagy (CASA) initiated by the cochaperone Bcl2-associated athanogene 3 (BAG3) represents an important mechanism for the disposal of misfolded and damaged proteins in mammalian cells. Under mechanical stress, the cochaperone cooperates with the small heat shock protein HSPB8 and the cytoskeleton-associated protein SYNPO2 to degrade force-unfolded forms of the actin-crosslinking protein filamin. This is essential for muscle maintenance in flies, fish, mice and men. Here, we identify the serine/threonine protein kinase 38 (STK38), which is part of the Hippo signaling network, as a novel interactor of BAG3. STK38 was previously shown to facilitate cytoskeleton assembly and to promote mitophagy as well as starvation and detachment induced autophagy. Significantly, our study reveals that STK38 exerts an inhibitory activity on BAG3-mediated autophagy. Inhibition relies on a disruption of the functional interplay of BAG3 with HSPB8 and SYNPO2 upon binding of STK38 to the cochaperone. Of note, STK38 attenuates CASA independently of its kinase activity, whereas previously established regulatory functions of STK38 involve target phosphorylation. The ability to exert different modes of regulation on central protein homeostasis (proteostasis) machineries apparently allows STK38 to coordinate the execution of diverse macroautophagy pathways and to balance cytoskeleton assembly and degradation. Abbreviations BAG3, BCL2-associated athanogene; CASA, chaperone-assisted selective autophagy; CHIP, carboxy terminus of HSP70 interacting protein; EPS, electrical pulse stimulation; GST, glutathione-S-transferase; mTOR, mechanistic target of rapamycin; mTORC1, mechanistic target of rapamycin complex 1; STK38, serine/threonine protein kinase 38." @default.
• W2898846475 created "2018-11-09" @default.
• W2898846475 creator A5017949552 @default.
• W2898846475 creator A5027329389 @default.
• W2898846475 creator A5041640381 @default.
• W2898846475 creator A5048109564 @default.
• W2898846475 creator A5057044540 @default.
• W2898846475 creator A5057675949 @default.
• W2898846475 creator A5070758909 @default.
• W2898846475 creator A5077777748 @default.
• W2898846475 date "2018-10-31" @default.
• W2898846475 modified "2023-10-01" @default.
• W2898846475 title "The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy" @default.
• W2898846475 cites W1549601788 @default.
• W2898846475 cites W1860864010 @default.
• W2898846475 cites W1909231446 @default.
• W2898846475 cites W1965352867 @default.
• W2898846475 cites W1974279922 @default.
• W2898846475 cites W1975489922 @default.
• W2898846475 cites W1980087135 @default.
• W2898846475 cites W1989618453 @default.
• W2898846475 cites W1998170956 @default.
• W2898846475 cites W1999600672 @default.
• W2898846475 cites W2005678965 @default.
• W2898846475 cites W2008334220 @default.
• W2898846475 cites W2013006994 @default.
• W2898846475 cites W2018956321 @default.
• W2898846475 cites W2024336151 @default.
• W2898846475 cites W2024789988 @default.
• W2898846475 cites W2025270890 @default.
• W2898846475 cites W2027212000 @default.
• W2898846475 cites W2030929478 @default.
• W2898846475 cites W2031111161 @default.
• W2898846475 cites W2032700869 @default.
• W2898846475 cites W2035901470 @default.
• W2898846475 cites W2039403501 @default.
• W2898846475 cites W2043882563 @default.
• W2898846475 cites W2044621729 @default.
• W2898846475 cites W2045373134 @default.
• W2898846475 cites W2050894712 @default.
• W2898846475 cites W2054150643 @default.
• W2898846475 cites W2056331158 @default.
• W2898846475 cites W2062312677 @default.
• W2898846475 cites W2066828912 @default.
• W2898846475 cites W2084875098 @default.
• W2898846475 cites W2094186182 @default.
• W2898846475 cites W2095442327 @default.
• W2898846475 cites W2106969933 @default.
• W2898846475 cites W2116896548 @default.
• W2898846475 cites W2118971140 @default.
• W2898846475 cites W2122179784 @default.
• W2898846475 cites W2129436528 @default.
• W2898846475 cites W2146337514 @default.
• W2898846475 cites W2147835547 @default.
• W2898846475 cites W2154979583 @default.
• W2898846475 cites W2158699410 @default.
• W2898846475 cites W2161199002 @default.
• W2898846475 cites W2170617996 @default.
• W2898846475 cites W2171417214 @default.
• W2898846475 cites W2171501785 @default.
• W2898846475 cites W2286263235 @default.
• W2898846475 cites W2287704006 @default.
• W2898846475 cites W2405928886 @default.
• W2898846475 cites W2414196255 @default.
• W2898846475 cites W2418628489 @default.
• W2898846475 cites W2517203221 @default.
• W2898846475 cites W2524900504 @default.
• W2898846475 cites W2533460394 @default.
• W2898846475 cites W2536572117 @default.
• W2898846475 cites W2555344087 @default.
• W2898846475 cites W2601850833 @default.
• W2898846475 cites W2604182146 @default.
• W2898846475 cites W2621097033 @default.
• W2898846475 cites W2626424052 @default.
• W2898846475 cites W2736393261 @default.
• W2898846475 cites W2737293726 @default.
• W2898846475 cites W2746160416 @default.
• W2898846475 cites W2782537152 @default.
• W2898846475 cites W2787291306 @default.
• W2898846475 cites W2904313966 @default.
• W2898846475 cites W2909537089 @default.
• W2898846475 doi "https://doi.org/10.1101/458323" @default.
• W2898846475 hasPublicationYear "2018" @default.
• W2898846475 type Work @default.
• W2898846475 sameAs 2898846475 @default.
• W2898846475 citedByCount "0" @default.
• W2898846475 crossrefType "posted-content" @default.
• W2898846475 hasAuthorship W2898846475A5017949552 @default.
• W2898846475 hasAuthorship W2898846475A5027329389 @default.
• W2898846475 hasAuthorship W2898846475A5041640381 @default.
• W2898846475 hasAuthorship W2898846475A5048109564 @default.
• W2898846475 hasAuthorship W2898846475A5057044540 @default.
• W2898846475 hasAuthorship W2898846475A5057675949 @default.
• W2898846475 hasAuthorship W2898846475A5070758909 @default.
• W2898846475 hasAuthorship W2898846475A5077777748 @default.
• W2898846475 hasBestOaLocation W28988464751 @default.
• W2898846475 hasConcept C11960822 @default.
• W2898846475 hasConcept C171896709 @default.
• W2898846475 hasConcept C172512520 @default.
• W2898846475 hasConcept C184235292 @default.

• next