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- W2898850495 abstract "Objectives: Heart failure (HF) qualifies as a research field to be prioritized in the application of metabolomic methodologies. This study addressed the consistency over time in the associations of early-stage diastolic left ventricular (LV) dysfunction with circulating metabolic markers. Methods: In 570 randomly recruited Flemish (50.1% women; mean age, 50.6 years), we assessed at a 5 year interval the multivariable-adjusted correlations of e’ and E/e¢ measured by tissue Doppler echocardiography with 43 circulating metabolites measured by nuclear magnetic resonance spectroscopy. Results: At follow-up, peak e¢ increased (Bonferroni corrected P ≤ 0.043) with valine, phosphocholine and glucose + taurine, while E/e¢ decreased (P ≤ 0.017) with valine and 2-oxybutyrate. Predicting from baseline marker levels, the risk of developing diastolic LV dysfunction (9.4%) or progressing from impaired relaxation to increased filling pressure (20.0%) was inversely correlated with glucose + taurine (P ≤ 0.0059). In analyses of the cross-sectional data at baseline and follow-up and the longitudinal data, markers consistently associated with better diastolic LV function included 2-aminobutyrate, leucine and 4-hydroxybutyrate, whereas those associated with worse function included glucose + glutamine. In pathway analysis, valine, leucine and isoleucine metabolism (log10p = 12.8) and aminoacyl tRNA biosynthesis (10.2) appeared as top paths associated with diastolic LV dysfunction. Conclusion: Among people covering the range from normal to asymptomatic diastolic LV dysfunction, associations of this trait with circulating metabolic markers were consistent over time. Our findings support a recent paradigm shift from glucose and fatty acids utilization to branched amino-acids metabolism in the pathogenesis of LV dysfunction." @default.
- W2898850495 created "2018-11-09" @default.
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- W2898850495 date "2018-10-01" @default.
- W2898850495 modified "2023-10-18" @default.
- W2898850495 title "A0203 Left Ventricular Function in Relation to Circulating Metabolic Biomarkers" @default.
- W2898850495 doi "https://doi.org/10.1097/01.hjh.0000547996.64510.cf" @default.
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