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• W2898853333 abstract "In recent years, the etiological study of oocyte maturation failure and other mechanisms of early embryonic development has gradually advanced. However, while some achievements have been made in this field, the intrinsic mechanisms underlying disordered oocyte maturation remain unclear. Polycomb group proteins (PcG) are a family of proteins that are involved in the epigenetic silencing of genes. Many members of this family are reportedly involved in mammalian oocyte maturation and early embryonic development. PHD finger protein 1 (PHF1) is a core member of the polycomblike group of proteins, although its role in oocyte maturation and early embryonic development are unknown. A previous study by our group using single cell transcriptome analysis and high-throughput technology revealed that PHF1 mRNA was elevated in the human oocyte and the early preimplantation embryo. This suggests that PHF1 may play an important role in oocyte maturation and early embryonic development. In the present study, we aimed to reveal the biological function of PHF1 in mouse oocyte maturation and illuminate its regulatory mechanisms. We report here, for the first time, that PHF1 is necessary for the accurate alignment of chromosomes and oocyte euploidy, as well for the regulation of the asymmetric division of oocytes in mouse. The results of the present study may have the potential to provide a new research direction of human oocyte maturation disorder and early embryonic development block. These results may also provide new diagnosis or treatment strategies for clinical patients." @default.
• W2898853333 created "2018-11-09" @default.
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• W2898853333 date "2018-11-11" @default.
• W2898853333 modified "2023-10-18" @default.
• W2898853333 title "PHF1 is required for chromosome alignment and asymmetric division during mouse meiotic oocyte maturation" @default.
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• W2898853333 doi "https://doi.org/10.1080/15384101.2018.1542896" @default.
• W2898853333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6342080" @default.
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