FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898854595> ?p ?o ?g. }

• W2898854595 endingPage "325" @default.
• W2898854595 startingPage "314" @default.
• W2898854595 abstract "Inflammation is hypothesized to be a key event in the growth of sporadic vestibular schwannoma (VS). In this study we sought to investigate the relationship between inflammation and tumor growth in vivo using the PET tracer 11C-(R)-PK11195 and dynamic contrast enhanced (DCE) MRI derived vascular biomarkers. Nineteen patients with sporadic VS (8 static, 7 growing, and 4 shrinking tumors) underwent prospective imaging with dynamic 11C-(R)-PK11195 PET and a comprehensive MR protocol, including high temporal resolution DCE-MRI in 15 patients. An intertumor comparison of 11C-(R)-PK11195 binding potential (BPND) and DCE-MRI derived vascular biomarkers (Ktrans, vp, ve) across the 3 different tumor growth cohorts was undertaken. Tissue of 8 tumors was examined with immunohistochemistry markers for inflammation (Iba1), neoplastic cells (S-100 protein), vessels (CD31), the PK11195 target translocator protein (TSPO), fibrinogen for vascular permeability, and proliferation (Ki-67). Results were correlated with PET and DCE-MRI data. Compared with static tumors, growing VS displayed significantly higher mean 11C-(R)-PK11195 BPND (−0.07 vs 0.47, P = 0.020), and higher mean tumor Ktrans (0.06 vs 0.14, P = 0.004). Immunohistochemistry confirmed the imaging findings and demonstrated that TSPO is predominantly expressed in macrophages. Within growing VS, macrophages rather than tumor cells accounted for the majority of proliferating cells. We present the first in vivo imaging evidence of increased inflammation within growing sporadic VS. Our results demonstrate that 11C-(R)-PK11195 specific binding and DCE-MRI derived parameters can be used as imaging biomarkers of inflammation and vascular permeability in this tumor group." @default.
• W2898854595 created "2018-11-09" @default.
• W2898854595 creator A5001060767 @default.
• W2898854595 creator A5003551209 @default.
• W2898854595 creator A5006508986 @default.
• W2898854595 creator A5008208747 @default.
• W2898854595 creator A5016226429 @default.
• W2898854595 creator A5016254151 @default.
• W2898854595 creator A5016484399 @default.
• W2898854595 creator A5020881340 @default.
• W2898854595 creator A5028246201 @default.
• W2898854595 creator A5028282904 @default.
• W2898854595 creator A5045539615 @default.
• W2898854595 creator A5046633002 @default.
• W2898854595 creator A5050219095 @default.
• W2898854595 creator A5050285347 @default.
• W2898854595 creator A5060002001 @default.
• W2898854595 creator A5066633235 @default.
• W2898854595 creator A5066934299 @default.
• W2898854595 creator A5068495335 @default.
• W2898854595 creator A5071060882 @default.
• W2898854595 creator A5072737251 @default.
• W2898854595 creator A5087003938 @default.
• W2898854595 creator A5089270646 @default.
• W2898854595 date "2018-11-02" @default.
• W2898854595 modified "2023-10-15" @default.
• W2898854595 title "Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma" @default.
• W2898854595 cites W1974482650 @default.
• W2898854595 cites W1975099250 @default.
• W2898854595 cites W1984483271 @default.
• W2898854595 cites W1988825906 @default.
• W2898854595 cites W1990940837 @default.
• W2898854595 cites W1991633087 @default.
• W2898854595 cites W2007490806 @default.
• W2898854595 cites W2018161909 @default.
• W2898854595 cites W2018432762 @default.
• W2898854595 cites W2018473639 @default.
• W2898854595 cites W2029881431 @default.
• W2898854595 cites W2029884260 @default.
• W2898854595 cites W2031648971 @default.
• W2898854595 cites W2038018468 @default.
• W2898854595 cites W2042098439 @default.
• W2898854595 cites W2042567095 @default.
• W2898854595 cites W2062244525 @default.
• W2898854595 cites W2070580351 @default.
• W2898854595 cites W2076455725 @default.
• W2898854595 cites W2083142752 @default.
• W2898854595 cites W2084037319 @default.
• W2898854595 cites W2091320739 @default.
• W2898854595 cites W2107418351 @default.
• W2898854595 cites W2108672941 @default.
• W2898854595 cites W2117671988 @default.
• W2898854595 cites W2118278569 @default.
• W2898854595 cites W2125281412 @default.
• W2898854595 cites W2130829870 @default.
• W2898854595 cites W2135999437 @default.
• W2898854595 cites W2142323667 @default.
• W2898854595 cites W2142340543 @default.
• W2898854595 cites W2145051661 @default.
• W2898854595 cites W2152938850 @default.
• W2898854595 cites W2154744699 @default.
• W2898854595 cites W2164024602 @default.
• W2898854595 cites W2166490777 @default.
• W2898854595 cites W2170249858 @default.
• W2898854595 cites W2170255457 @default.
• W2898854595 cites W2218004332 @default.
• W2898854595 cites W2307247095 @default.
• W2898854595 cites W2325367708 @default.
• W2898854595 cites W2325389482 @default.
• W2898854595 cites W2397693996 @default.
• W2898854595 cites W2535267779 @default.
• W2898854595 cites W2621806352 @default.
• W2898854595 cites W2791334309 @default.
• W2898854595 cites W620040269 @default.
• W2898854595 doi "https://doi.org/10.1093/neuonc/noy177" @default.
• W2898854595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6380424" @default.
• W2898854595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30388263" @default.
• W2898854595 hasPublicationYear "2018" @default.
• W2898854595 type Work @default.
• W2898854595 sameAs 2898854595 @default.
• W2898854595 citedByCount "56" @default.
• W2898854595 countsByYear W28988545952019 @default.
• W2898854595 countsByYear W28988545952020 @default.
• W2898854595 countsByYear W28988545952021 @default.
• W2898854595 countsByYear W28988545952022 @default.
• W2898854595 countsByYear W28988545952023 @default.
• W2898854595 crossrefType "journal-article" @default.
• W2898854595 hasAuthorship W2898854595A5001060767 @default.
• W2898854595 hasAuthorship W2898854595A5003551209 @default.
• W2898854595 hasAuthorship W2898854595A5006508986 @default.
• W2898854595 hasAuthorship W2898854595A5008208747 @default.
• W2898854595 hasAuthorship W2898854595A5016226429 @default.
• W2898854595 hasAuthorship W2898854595A5016254151 @default.
• W2898854595 hasAuthorship W2898854595A5016484399 @default.
• W2898854595 hasAuthorship W2898854595A5020881340 @default.
• W2898854595 hasAuthorship W2898854595A5028246201 @default.
• W2898854595 hasAuthorship W2898854595A5028282904 @default.
• W2898854595 hasAuthorship W2898854595A5045539615 @default.

• next