FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898855467> ?p ?o ?g. }

• W2898855467 abstract "Abstract Most of the millions of single-nucleotide polymorphisms (SNPs) in the human genome are non-coding, and many overlap with putative regulatory elements. Genome-wide association studies have linked many of these SNPs to human traits or to gene expression levels, but rarely with sufficient resolution to identify the causal SNPs. Functional screens based on reporter assays have previously been of insufficient throughput to test the vast space of SNPs for possible effects on enhancer and promoter activity. Here, we have leveraged the throughput of the SuRE reporter technology to survey a total of 5.9 million SNPs, including 57% of the known common SNPs. We identified more than 30 thousand SNPs that alter the activity of putative regulatory elements, often in a cell-type specific manner. These data indicate that a large proportion of human non-coding SNPs may affect gene regulation. Integration of these SuRE data with genome-wide association studies may help pinpoint SNPs that underlie human traits." @default.
• W2898855467 created "2018-11-09" @default.
• W2898855467 creator A5002058399 @default.
• W2898855467 creator A5014412428 @default.
• W2898855467 creator A5023715777 @default.
• W2898855467 creator A5036529265 @default.
• W2898855467 creator A5059305245 @default.
• W2898855467 creator A5060964091 @default.
• W2898855467 creator A5062681183 @default.
• W2898855467 creator A5063941081 @default.
• W2898855467 creator A5065418263 @default.
• W2898855467 creator A5073346894 @default.
• W2898855467 creator A5079048868 @default.
• W2898855467 creator A5081340727 @default.
• W2898855467 creator A5082560822 @default.
• W2898855467 creator A5088511146 @default.
• W2898855467 date "2018-11-04" @default.
• W2898855467 modified "2023-10-01" @default.
• W2898855467 title "Systematic identification of human SNPs affecting regulatory element activity" @default.
• W2898855467 cites W1652565430 @default.
• W2898855467 cites W1796801877 @default.
• W2898855467 cites W1912312559 @default.
• W2898855467 cites W1973094248 @default.
• W2898855467 cites W1981153918 @default.
• W2898855467 cites W1993243592 @default.
• W2898855467 cites W1993616000 @default.
• W2898855467 cites W2012150510 @default.
• W2898855467 cites W2023342647 @default.
• W2898855467 cites W2024871697 @default.
• W2898855467 cites W2029530775 @default.
• W2898855467 cites W2033202128 @default.
• W2898855467 cites W2038331078 @default.
• W2898855467 cites W2064815984 @default.
• W2898855467 cites W2076657727 @default.
• W2898855467 cites W2080752012 @default.
• W2898855467 cites W2099259774 @default.
• W2898855467 cites W2104116111 @default.
• W2898855467 cites W2104549677 @default.
• W2898855467 cites W2106070783 @default.
• W2898855467 cites W2107596936 @default.
• W2898855467 cites W2112673809 @default.
• W2898855467 cites W2116400584 @default.
• W2898855467 cites W2134567338 @default.
• W2898855467 cites W2148070136 @default.
• W2898855467 cites W2159417227 @default.
• W2898855467 cites W2170551349 @default.
• W2898855467 cites W2195359644 @default.
• W2898855467 cites W2202219635 @default.
• W2898855467 cites W2221356560 @default.
• W2898855467 cites W2256016639 @default.
• W2898855467 cites W2259938310 @default.
• W2898855467 cites W2412481123 @default.
• W2898855467 cites W2413629639 @default.
• W2898855467 cites W2481378334 @default.
• W2898855467 cites W2550031966 @default.
• W2898855467 cites W2559028527 @default.
• W2898855467 cites W2559699708 @default.
• W2898855467 cites W2560119881 @default.
• W2898855467 cites W2560383108 @default.
• W2898855467 cites W2566958422 @default.
• W2898855467 cites W2612643019 @default.
• W2898855467 cites W2747782741 @default.
• W2898855467 cites W2761275051 @default.
• W2898855467 cites W2766421346 @default.
• W2898855467 cites W2770178180 @default.
• W2898855467 cites W2801470635 @default.
• W2898855467 cites W2801760002 @default.
• W2898855467 cites W2803198744 @default.
• W2898855467 cites W2806225217 @default.
• W2898855467 cites W2837542075 @default.
• W2898855467 cites W4247053599 @default.
• W2898855467 doi "https://doi.org/10.1101/460402" @default.
• W2898855467 hasPublicationYear "2018" @default.
• W2898855467 type Work @default.
• W2898855467 sameAs 2898855467 @default.
• W2898855467 citedByCount "5" @default.
• W2898855467 countsByYear W28988554672019 @default.
• W2898855467 countsByYear W28988554672020 @default.
• W2898855467 countsByYear W28988554672022 @default.
• W2898855467 crossrefType "posted-content" @default.
• W2898855467 hasAuthorship W2898855467A5002058399 @default.
• W2898855467 hasAuthorship W2898855467A5014412428 @default.
• W2898855467 hasAuthorship W2898855467A5023715777 @default.
• W2898855467 hasAuthorship W2898855467A5036529265 @default.
• W2898855467 hasAuthorship W2898855467A5059305245 @default.
• W2898855467 hasAuthorship W2898855467A5060964091 @default.
• W2898855467 hasAuthorship W2898855467A5062681183 @default.
• W2898855467 hasAuthorship W2898855467A5063941081 @default.
• W2898855467 hasAuthorship W2898855467A5065418263 @default.
• W2898855467 hasAuthorship W2898855467A5073346894 @default.
• W2898855467 hasAuthorship W2898855467A5079048868 @default.
• W2898855467 hasAuthorship W2898855467A5081340727 @default.
• W2898855467 hasAuthorship W2898855467A5082560822 @default.
• W2898855467 hasAuthorship W2898855467A5088511146 @default.
• W2898855467 hasBestOaLocation W28988554671 @default.
• W2898855467 hasConcept C104317684 @default.
• W2898855467 hasConcept C106208931 @default.
• W2898855467 hasConcept C111936080 @default.
• W2898855467 hasConcept C135763542 @default.
• W2898855467 hasConcept C141231307 @default.

• next