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- W2898856552 abstract "Background Vitamin D may have a potential role in rheumatoid arthritis (RA) pathogenesis by inhibiting the expression of pro-inflammatory cytokines including interleukin-6 (IL-6)1–2. Objectives The aim of this study is to determine the clinical factors of vitamin D deficiency in a multi-ethnic Malaysian RA patients and its association with disease activity, functional disability and serum IL-6 level. Methods One-hundred RA patients and 50 healthy controls, age- and sex-matched were recruited. DAS28 and HAQ score were assessed. Baseline serum vitamin D and IL-6 were measured in all subjects. RA patients who were vitamin D deficient were given loading dose of vitamin D3 and repeated assessments were done. Results Vitamin D deficiency ( Conclusions Vitamin D deficiency is prevalent in Malaysian RA patients. This study suggests that vitamin D does not have a role in disease activity or serum IL-6 but it may have a role in functional disability in RA patients. References [1] van Hamburg JP, et al.TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation. Ann Rheum Dis,2012.71(4):606–12 [2] Wen H, et al. 1,25 (OH) 2-Vitamin-D3 attenuates Th17-related cytokines expression in peripheral blood mononuclear cells in patients with early-diagnosed rheumatoid arthritis. Zhonghua nei ke za zhi,2015.54(4):317–21 Acknowledgements We thank Arthritis Foundation Malaysia for the financial support of this study. Disclosure of Interest None declared" @default.
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- W2898856552 date "2018-06-01" @default.
- W2898856552 modified "2023-09-27" @default.
- W2898856552 title "AB1312 Effects of vitamin d on disease activity, functional disability and serum interleukin-6 in rheumatoid arthritis" @default.
- W2898856552 doi "https://doi.org/10.1136/annrheumdis-2018-eular.1675" @default.
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