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• W2898856971 abstract "Recombinant adeno-associated viruses (AAVs) are emerging as favoured transgene delivery vectors for both research applications and gene therapy. In this context, a thorough investigation of the potential of various AAV serotypes to transduce specific cell types is valuable. Here, we rigorously tested the infectivity of a number of AAV serotypes in murine testis by direct testicular injection. We report the tropism of serotypes AAV2, 5, 8, 9 and AAVrh10 in mouse testis. We reveal unique infectivity of AAV2 and AAV9, which preferentially target intertubular testosterone-producing Leydig cells. Remarkably, AAV2 TM, a mutant for capsid designed to increase transduction, displayed a dramatic alteration in tropism; it infiltrated seminiferous tubules unlike wildtype AAV2 and transduced Sertoli cells. However, none of the AAVs tested infected spermatogonial cells. In spite of direct testicular injection, none of the tested AAVs appeared to infect sperm progenitors as assayed by reporter expression. This lends support to the current view that AAVs are safe gene-therapy vehicles. However, testing the presence of rAAV genomic DNA in germ cells is necessary to assess the risk of individual serotypes." @default.
• W2898856971 created "2018-11-09" @default.
• W2898856971 creator A5001804147 @default.
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• W2898856971 date "2018-11-01" @default.
• W2898856971 modified "2023-10-16" @default.
• W2898856971 title "Infectivity of adeno-associated virus serotypes in mouse testis" @default.
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• W2898856971 doi "https://doi.org/10.1186/s12896-018-0479-1" @default.
• W2898856971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6211462" @default.
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