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- W2898857252 abstract "Myasthenia gravis je autoimunitni onemocněni s produkci protilatek proti některým proteinům na postsynapticke membraně nervosvalove plotenky, zejmena acetylcholinovemu receptoru. V důsledku toho dochazi k manifestaci svalove slabosti a unavitelnosti. Lecba je symptomaticka, ovlivněni imunopatogeneze onemocněni spociva v dlouhodobem podavani imunosupresiv nebo imunomodulacnich leciv. Tato lecba může být nespecificka s redukci autoreaktivnich B nebo T lymfocytů, nebo specificka, pomoci monoklonalnich protilatek, ktere cili na buněcne povrchove znaky. Lecba je chronicka, s cilem navozeni klinicke remise. K ovlivněni urgentnich stavů s ohroženim života (myastenicka krize) je použivana lecba akutni. Některe leky mohou negativně ovlivnit nervosvalový přenos a tim manifestovat latentni onemocněni, nebo zhorsit průběh choroby." @default.
- W2898857252 created "2018-11-09" @default.
- W2898857252 creator A5079124974 @default.
- W2898857252 date "2018-08-13" @default.
- W2898857252 modified "2023-10-17" @default.
- W2898857252 title "The role of pharmacotherapy in the treatment of myasthenia gravis" @default.
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- W2898857252 doi "https://doi.org/10.36290/far.2018.009" @default.
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