FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898858223> ?p ?o ?g. }

• W2898858223 endingPage "89" @default.
• W2898858223 startingPage "81" @default.
• W2898858223 abstract "Minimal residual disease (MRD) monitoring is a powerful tool to predict the risk of relapse. Herein, we present an MRD monitoring strategy for B-cell lymphoblastic leukemia (B-ALL) using high-throughput sequencing (HTS) of immunoglobulin (Ig) clonality before implementation into routine practice.We selected 74 bone marrow (BM) specimens from 47 patients who were diagnosed with B-ALL. Ig clonality was analyzed using both fragment analysis and HTS. The performance of Ig clonality was evaluated through comparison of the results from real-time quantitative polymerase chain reaction (qPCR) of leukemia-specific fusion transcripts and flow cytometry.IGH clonality was observed in all patients, and the sum of clonal burden varied (9.47%-96.77%). IGK clonality was identified in 70% of patients and availed in cases with low IGH clonal burden. The total IGH clonal burden was significantly correlated with the proportion of leukemic blasts, leukemia-specific fusion transcripts, and flow cytometry. We recognized the different responses of each clone and emerging clones originating from the trace of Ig rearrangement presented in the initial specimen. IGH clonal burden after chemotherapy represented patient outcomes well. IGH assay also provided information of repertoire diversity of IGH rearrangement.The Ig clonality assay via HTS will be a promising tool for MRD monitoring of B-ALL through an adequate strategy to identify and monitor individual clones and determine repertoire diversity." @default.
• W2898858223 created "2018-11-09" @default.
• W2898858223 creator A5002232086 @default.
• W2898858223 creator A5005460447 @default.
• W2898858223 creator A5007030693 @default.
• W2898858223 creator A5009770843 @default.
• W2898858223 creator A5014044521 @default.
• W2898858223 creator A5021499196 @default.
• W2898858223 creator A5036020306 @default.
• W2898858223 creator A5043910009 @default.
• W2898858223 creator A5049274095 @default.
• W2898858223 creator A5060874168 @default.
• W2898858223 creator A5064560942 @default.
• W2898858223 creator A5077849701 @default.
• W2898858223 creator A5079417302 @default.
• W2898858223 creator A5081811380 @default.
• W2898858223 date "2019-01-01" @default.
• W2898858223 modified "2023-10-06" @default.
• W2898858223 title "Considerations for monitoring minimal residual disease using immunoglobulin clonality in patients with precursor B-cell lymphoblastic leukemia" @default.
• W2898858223 cites W1239385015 @default.
• W2898858223 cites W1972308638 @default.
• W2898858223 cites W2010678060 @default.
• W2898858223 cites W2019359431 @default.
• W2898858223 cites W2020094108 @default.
• W2898858223 cites W2045807214 @default.
• W2898858223 cites W2063241612 @default.
• W2898858223 cites W2069702102 @default.
• W2898858223 cites W2130273468 @default.
• W2898858223 cites W2142519069 @default.
• W2898858223 cites W2168109746 @default.
• W2898858223 cites W2169047291 @default.
• W2898858223 cites W2171240476 @default.
• W2898858223 cites W2175702062 @default.
• W2898858223 cites W2274803986 @default.
• W2898858223 cites W2277930726 @default.
• W2898858223 cites W2329186770 @default.
• W2898858223 cites W2393357531 @default.
• W2898858223 cites W2554048125 @default.
• W2898858223 cites W2576052323 @default.
• W2898858223 cites W2587199293 @default.
• W2898858223 cites W2609221159 @default.
• W2898858223 cites W2624475720 @default.
• W2898858223 doi "https://doi.org/10.1016/j.cca.2018.10.037" @default.
• W2898858223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30389459" @default.
• W2898858223 hasPublicationYear "2019" @default.
• W2898858223 type Work @default.
• W2898858223 sameAs 2898858223 @default.
• W2898858223 citedByCount "7" @default.
• W2898858223 countsByYear W28988582232019 @default.
• W2898858223 countsByYear W28988582232020 @default.
• W2898858223 countsByYear W28988582232021 @default.
• W2898858223 countsByYear W28988582232022 @default.
• W2898858223 countsByYear W28988582232023 @default.
• W2898858223 crossrefType "journal-article" @default.
• W2898858223 hasAuthorship W2898858223A5002232086 @default.
• W2898858223 hasAuthorship W2898858223A5005460447 @default.
• W2898858223 hasAuthorship W2898858223A5007030693 @default.
• W2898858223 hasAuthorship W2898858223A5009770843 @default.
• W2898858223 hasAuthorship W2898858223A5014044521 @default.
• W2898858223 hasAuthorship W2898858223A5021499196 @default.
• W2898858223 hasAuthorship W2898858223A5036020306 @default.
• W2898858223 hasAuthorship W2898858223A5043910009 @default.
• W2898858223 hasAuthorship W2898858223A5049274095 @default.
• W2898858223 hasAuthorship W2898858223A5060874168 @default.
• W2898858223 hasAuthorship W2898858223A5064560942 @default.
• W2898858223 hasAuthorship W2898858223A5077849701 @default.
• W2898858223 hasAuthorship W2898858223A5079417302 @default.
• W2898858223 hasAuthorship W2898858223A5081811380 @default.
• W2898858223 hasConcept C104317684 @default.
• W2898858223 hasConcept C153911025 @default.
• W2898858223 hasConcept C159654299 @default.
• W2898858223 hasConcept C203014093 @default.
• W2898858223 hasConcept C2778453870 @default.
• W2898858223 hasConcept C2778461978 @default.
• W2898858223 hasConcept C2779823535 @default.
• W2898858223 hasConcept C2780007613 @default.
• W2898858223 hasConcept C49105822 @default.
• W2898858223 hasConcept C54355233 @default.
• W2898858223 hasConcept C553184892 @default.
• W2898858223 hasConcept C81089528 @default.
• W2898858223 hasConcept C86803240 @default.
• W2898858223 hasConcept C96007430 @default.
• W2898858223 hasConceptScore W2898858223C104317684 @default.
• W2898858223 hasConceptScore W2898858223C153911025 @default.
• W2898858223 hasConceptScore W2898858223C159654299 @default.
• W2898858223 hasConceptScore W2898858223C203014093 @default.
• W2898858223 hasConceptScore W2898858223C2778453870 @default.
• W2898858223 hasConceptScore W2898858223C2778461978 @default.
• W2898858223 hasConceptScore W2898858223C2779823535 @default.
• W2898858223 hasConceptScore W2898858223C2780007613 @default.
• W2898858223 hasConceptScore W2898858223C49105822 @default.
• W2898858223 hasConceptScore W2898858223C54355233 @default.
• W2898858223 hasConceptScore W2898858223C553184892 @default.
• W2898858223 hasConceptScore W2898858223C81089528 @default.
• W2898858223 hasConceptScore W2898858223C86803240 @default.
• W2898858223 hasConceptScore W2898858223C96007430 @default.
• W2898858223 hasFunder F4320321379 @default.
• W2898858223 hasLocation W28988582231 @default.

• next