FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898864613> ?p ?o ?g. }

• W2898864613 endingPage "553" @default.
• W2898864613 startingPage "541" @default.
• W2898864613 abstract "Current asthma therapies fail to target airway remodeling that correlates with asthma severity driving disease progression that ultimately leads to loss of lung function. Macroautophagy (hereinafter autophagy) is a fundamental cell-recycling mechanism in all eukaryotic cells; emerging evidence suggests that it is dysregulated in asthma. We investigated the interrelationship between autophagy and airway remodeling and assessed preclinical efficacy of a known autophagy inhibitor in murine models of asthma. Human asthmatic and nonasthmatic lung tissues were histologically evaluated and were immunostained for key autophagy markers. The percentage area of positive staining was quantified in the epithelium and airway smooth muscle bundles using ImageJ software. Furthermore, the autophagy inhibitor chloroquine was tested intranasally in prophylactic (3 wk) and treatment (5 wk) models of allergic asthma in mice. Human asthmatic tissues showed greater tissue inflammation and demonstrated hallmark features of airway remodeling, displaying thickened epithelium (P < 0.001) and reticular basement membrane (P < 0.0001), greater lamina propria depth (P < 0.005), and increased airway smooth muscle bundles (P < 0.001) with higher expression of Beclin-1 (P < 0.01) and ATG5 (autophagy-related gene 5) (P < 0.05) together with reduced p62 (P < 0.05) compared with nonasthmatic control tissues. Beclin-1 expression was significantly higher in asthmatic epithelium and ciliated cells (P < 0.05), suggesting a potential role of ciliophagy in asthma. Murine asthma models demonstrated effective preclinical efficacy (reduced key features of allergic asthma: airway inflammation, airway hyperresponsiveness, and airway remodeling) of the autophagy inhibitor chloroquine. Our data demonstrate cell context-dependent and selective activation of autophagy in structural cells in asthma. Furthermore, this pathway can be effectively targeted to ameliorate airway remodeling in asthma." @default.
• W2898864613 created "2018-11-09" @default.
• W2898864613 creator A5011446102 @default.
• W2898864613 creator A5025601361 @default.
• W2898864613 creator A5053777899 @default.
• W2898864613 creator A5059244618 @default.
• W2898864613 creator A5062304643 @default.
• W2898864613 creator A5074742233 @default.
• W2898864613 creator A5079372560 @default.
• W2898864613 creator A5084474144 @default.
• W2898864613 date "2019-05-01" @default.
• W2898864613 modified "2023-10-18" @default.
• W2898864613 title "Autophagy Activation in Asthma Airways Remodeling" @default.
• W2898864613 cites W1508661542 @default.
• W2898864613 cites W1523693806 @default.
• W2898864613 cites W1529396499 @default.
• W2898864613 cites W1551700340 @default.
• W2898864613 cites W155251221 @default.
• W2898864613 cites W1839043230 @default.
• W2898864613 cites W1987566410 @default.
• W2898864613 cites W1987769185 @default.
• W2898864613 cites W1996936400 @default.
• W2898864613 cites W2005270729 @default.
• W2898864613 cites W2006239481 @default.
• W2898864613 cites W2037248554 @default.
• W2898864613 cites W2048030072 @default.
• W2898864613 cites W2048205090 @default.
• W2898864613 cites W2053664189 @default.
• W2898864613 cites W2057060268 @default.
• W2898864613 cites W2063114687 @default.
• W2898864613 cites W2079666008 @default.
• W2898864613 cites W2079694744 @default.
• W2898864613 cites W2080494706 @default.
• W2898864613 cites W2081057817 @default.
• W2898864613 cites W2082229309 @default.
• W2898864613 cites W2085016639 @default.
• W2898864613 cites W2087920955 @default.
• W2898864613 cites W2088832772 @default.
• W2898864613 cites W2093295909 @default.
• W2898864613 cites W2102112528 @default.
• W2898864613 cites W2104383425 @default.
• W2898864613 cites W2108995183 @default.
• W2898864613 cites W2109034822 @default.
• W2898864613 cites W2115219176 @default.
• W2898864613 cites W2118295402 @default.
• W2898864613 cites W2118676765 @default.
• W2898864613 cites W2118834593 @default.
• W2898864613 cites W2119878648 @default.
• W2898864613 cites W2130434435 @default.
• W2898864613 cites W2131089732 @default.
• W2898864613 cites W2131758520 @default.
• W2898864613 cites W2132297922 @default.
• W2898864613 cites W2133302347 @default.
• W2898864613 cites W2133864761 @default.
• W2898864613 cites W2150805904 @default.
• W2898864613 cites W2159035725 @default.
• W2898864613 cites W2164778558 @default.
• W2898864613 cites W2166073723 @default.
• W2898864613 cites W2582480512 @default.
• W2898864613 cites W2590346195 @default.
• W2898864613 cites W2603793890 @default.
• W2898864613 cites W2611053924 @default.
• W2898864613 cites W2761109864 @default.
• W2898864613 cites W2765788534 @default.
• W2898864613 cites W2790614817 @default.
• W2898864613 doi "https://doi.org/10.1165/rcmb.2018-0169oc" @default.
• W2898864613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6503620" @default.
• W2898864613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30383396" @default.
• W2898864613 hasPublicationYear "2019" @default.
• W2898864613 type Work @default.
• W2898864613 sameAs 2898864613 @default.
• W2898864613 citedByCount "99" @default.
• W2898864613 countsByYear W28988646132019 @default.
• W2898864613 countsByYear W28988646132020 @default.
• W2898864613 countsByYear W28988646132021 @default.
• W2898864613 countsByYear W28988646132022 @default.
• W2898864613 countsByYear W28988646132023 @default.
• W2898864613 crossrefType "journal-article" @default.
• W2898864613 hasAuthorship W2898864613A5011446102 @default.
• W2898864613 hasAuthorship W2898864613A5025601361 @default.
• W2898864613 hasAuthorship W2898864613A5053777899 @default.
• W2898864613 hasAuthorship W2898864613A5059244618 @default.
• W2898864613 hasAuthorship W2898864613A5062304643 @default.
• W2898864613 hasAuthorship W2898864613A5074742233 @default.
• W2898864613 hasAuthorship W2898864613A5079372560 @default.
• W2898864613 hasAuthorship W2898864613A5084474144 @default.
• W2898864613 hasBestOaLocation W28988646132 @default.
• W2898864613 hasConcept C105922876 @default.
• W2898864613 hasConcept C126322002 @default.
• W2898864613 hasConcept C141071460 @default.
• W2898864613 hasConcept C142724271 @default.
• W2898864613 hasConcept C190283241 @default.
• W2898864613 hasConcept C203014093 @default.
• W2898864613 hasConcept C203522944 @default.
• W2898864613 hasConcept C2776042228 @default.
• W2898864613 hasConcept C2776914184 @default.
• W2898864613 hasConcept C2777714996 @default.
• W2898864613 hasConcept C529295009 @default.

• next