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- W2898865175 abstract "The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2 ] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl2 ] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs." @default.
- W2898865175 created "2018-11-09" @default.
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- W2898865175 date "2018-11-27" @default.
- W2898865175 modified "2023-10-14" @default.
- W2898865175 title "In vitro Anti‐atherogenic Properties of N‐Heterocyclic Carbene Aurate(I) Compounds" @default.
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- W2898865175 doi "https://doi.org/10.1002/cmdc.201800601" @default.
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