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• W2898867690 abstract "Abstract A transcriptional feedback loop is central to clock function in animals, plants and fungi. The clock genes involved in its regulation are specific to - and highly conserved within - the kingdoms of life. However, other shared clock mechanisms, such as phosphorylation, are mediated by proteins found broadly among living organisms, performing functions in many cellular sub-systems. Use of homology to directly infer involvement/association with the clock mechanism in new, developing model systems, is therefore of limited use. Here we describe the approach PREMONition, PRE dicting M olecular N etworks, that uses functional relationships to predict molecular circadian clock associations. PREMONition is based on the incorporation of proteins encoded by known clock genes (when available), rhythmically expressed clock-controlled genes and non-rhythmically expressed but interacting genes into a cohesive network. After tuning PREMONition on the networks derived for human, fly and fungal circadian clocks, we deployed the approach to predict a molecular clock network for Saccharomyces cerevisiae , for which there are no readily-identifiable clock gene homologs. The predicted network was validated using gene expression data and a growth assay for sensitivity to light, a zeitgeber of circadian clocks of most organisms. PREMONition may be used to identify candidate clock-regulated processes and thus candidate clock genes in other organisms." @default.
• W2898867690 created "2018-11-09" @default.
• W2898867690 creator A5040416265 @default.
• W2898867690 creator A5047968488 @default.
• W2898867690 creator A5052789904 @default.
• W2898867690 creator A5056123757 @default.
• W2898867690 date "2018-11-05" @default.
• W2898867690 modified "2023-09-26" @default.
• W2898867690 title "PREMONition: An algorithm for predicting the circadian clock-regulated molecular network" @default.
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• W2898867690 doi "https://doi.org/10.1101/463190" @default.
• W2898867690 hasPublicationYear "2018" @default.
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