FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898873016> ?p ?o ?g. }

• W2898873016 endingPage "22" @default.
• W2898873016 startingPage "11" @default.
• W2898873016 abstract "In Alzheimer's disease (AD), characterized by cognitive deterioration, synaptic alterations are frequently reported. The TgCRND8 model, in which mice develop AD-like amyloid β plaque formation, has been used to investigate the effects of amyloidosis on synaptic function. Background strain impacts the behavioral and neuropathological phenotype of mice in this model, but whether this extends to synaptic function is unknown. We investigated the influence of background strain on basal synaptic transmission and long-term potentiation (LTP) in the hippocampus of TgCRND8 mice (13–16 months) on hybrid backgrounds of (129SvEv/Tac) x (C3H/C57/129SvEv/Tac) (aka “129”) or (C57) x (C3H/C57) (aka “C3H”). In littermate controls, basal synaptic transmission was significantly reduced, whereas the amplitude of excitatory postsynaptic potentials was significantly higher after LTP induction in 129 vs. C3H mice. In 129 TgCRND8 mice, deficits in hippocampal LTP were more severe than in C3H TgCRND8 relative to controls. Compared to controls, network excitability was decreased in transgenics from both strains. These data suggest that 129 TgCRND8 mice are the more appropriate model to evaluate the efficacy of potential AD treatments on synaptic function, owing to their significant deficit in LTP. Such studies are critical in order to improve the translational capacity of basic science research." @default.
• W2898873016 created "2018-11-09" @default.
• W2898873016 creator A5001982850 @default.
• W2898873016 creator A5049787571 @default.
• W2898873016 creator A5087268355 @default.
• W2898873016 creator A5091036633 @default.
• W2898873016 date "2019-01-01" @default.
• W2898873016 modified "2023-09-29" @default.
• W2898873016 title "Strain differences in hippocampal synaptic dysfunction in the TgCRND8 mouse model of Alzheimer's disease: Implications for improving translational capacity" @default.
• W2898873016 cites W1483057098 @default.
• W2898873016 cites W1718512444 @default.
• W2898873016 cites W1758002729 @default.
• W2898873016 cites W1973533307 @default.
• W2898873016 cites W1974073785 @default.
• W2898873016 cites W1975311211 @default.
• W2898873016 cites W1975727393 @default.
• W2898873016 cites W1990752558 @default.
• W2898873016 cites W1993846845 @default.
• W2898873016 cites W2005506557 @default.
• W2898873016 cites W2008776671 @default.
• W2898873016 cites W2011567013 @default.
• W2898873016 cites W2014228329 @default.
• W2898873016 cites W2021884016 @default.
• W2898873016 cites W2023078600 @default.
• W2898873016 cites W2023395361 @default.
• W2898873016 cites W2031346817 @default.
• W2898873016 cites W2034352381 @default.
• W2898873016 cites W2034434521 @default.
• W2898873016 cites W2034579217 @default.
• W2898873016 cites W2035880579 @default.
• W2898873016 cites W2036580198 @default.
• W2898873016 cites W2049511526 @default.
• W2898873016 cites W2053487887 @default.
• W2898873016 cites W2054975255 @default.
• W2898873016 cites W2055030770 @default.
• W2898873016 cites W2059546301 @default.
• W2898873016 cites W2061525620 @default.
• W2898873016 cites W2071390704 @default.
• W2898873016 cites W2080340410 @default.
• W2898873016 cites W2087960997 @default.
• W2898873016 cites W2092426413 @default.
• W2898873016 cites W2095294770 @default.
• W2898873016 cites W2095484045 @default.
• W2898873016 cites W2095595908 @default.
• W2898873016 cites W2106259210 @default.
• W2898873016 cites W2127762763 @default.
• W2898873016 cites W2130784302 @default.
• W2898873016 cites W2133579501 @default.
• W2898873016 cites W2140360945 @default.
• W2898873016 cites W2142349181 @default.
• W2898873016 cites W2146561158 @default.
• W2898873016 cites W2153747061 @default.
• W2898873016 cites W2155729263 @default.
• W2898873016 cites W2163301650 @default.
• W2898873016 cites W2169308121 @default.
• W2898873016 cites W2403699353 @default.
• W2898873016 cites W2912715604 @default.
• W2898873016 doi "https://doi.org/10.1016/j.mcn.2018.10.005" @default.
• W2898873016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30404024" @default.
• W2898873016 hasPublicationYear "2019" @default.
• W2898873016 type Work @default.
• W2898873016 sameAs 2898873016 @default.
• W2898873016 citedByCount "2" @default.
• W2898873016 countsByYear W28988730162021 @default.
• W2898873016 countsByYear W28988730162023 @default.
• W2898873016 crossrefType "journal-article" @default.
• W2898873016 hasAuthorship W2898873016A5001982850 @default.
• W2898873016 hasAuthorship W2898873016A5049787571 @default.
• W2898873016 hasAuthorship W2898873016A5087268355 @default.
• W2898873016 hasAuthorship W2898873016A5091036633 @default.
• W2898873016 hasConcept C112592302 @default.
• W2898873016 hasConcept C126322002 @default.
• W2898873016 hasConcept C148762608 @default.
• W2898873016 hasConcept C169760540 @default.
• W2898873016 hasConcept C170493617 @default.
• W2898873016 hasConcept C17077164 @default.
• W2898873016 hasConcept C200170125 @default.
• W2898873016 hasConcept C25274449 @default.
• W2898873016 hasConcept C2779134260 @default.
• W2898873016 hasConcept C2781161787 @default.
• W2898873016 hasConcept C502032728 @default.
• W2898873016 hasConcept C55493867 @default.
• W2898873016 hasConcept C71924100 @default.
• W2898873016 hasConcept C86803240 @default.
• W2898873016 hasConcept C98229152 @default.
• W2898873016 hasConceptScore W2898873016C112592302 @default.
• W2898873016 hasConceptScore W2898873016C126322002 @default.
• W2898873016 hasConceptScore W2898873016C148762608 @default.
• W2898873016 hasConceptScore W2898873016C169760540 @default.
• W2898873016 hasConceptScore W2898873016C170493617 @default.
• W2898873016 hasConceptScore W2898873016C17077164 @default.
• W2898873016 hasConceptScore W2898873016C200170125 @default.
• W2898873016 hasConceptScore W2898873016C25274449 @default.
• W2898873016 hasConceptScore W2898873016C2779134260 @default.
• W2898873016 hasConceptScore W2898873016C2781161787 @default.
• W2898873016 hasConceptScore W2898873016C502032728 @default.
• W2898873016 hasConceptScore W2898873016C55493867 @default.
• W2898873016 hasConceptScore W2898873016C71924100 @default.

• next