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• W2898879062 abstract "AAlzheimer’s disease and other similar dementias are debilitating neurodegenerative disorders whose aetiology and pathogenesis remain largely unknown, even after decades of research. With the anticipated increase in prevalence of Alzheimer’s disease among the more susceptible ageing population, the need for disease-modifying treatments is urgent. While various hypotheses have been put forward over the last few decades, we suggest that sporadic Alzheimer’s disease is triggered by external environmental factors, co-expressing in individuals with specific genetic susceptibilities. These external stressors are defined in the Iron Dysregulation and Dormant Microbes (IDDM) hypothesis, previously put forward. This hypothesis is consistent with current literature in which serum ferritin levels of individuals diagnosed with Alzheimer’s disease are significantly higher compared those of age- and gender-matched controls. While iron dysregulation contributes to oxidative stress, it also causes microbial reactivation and virulence of the so-called dormant blood (and tissue) microbiome. Dysbiosis (changes in the microbiome) or previous infections can contribute to the dormant blood microbiome (atopobiosis), and they also directly promote systemic inflammation via the amyloidogenic formation and shedding of potent inflammagens such as lipopolysaccharides. The simultaneous iron dysregulation and microbial aberrations affect the haematological system, promoting fibrin amylodiogenesis and pathological clotting. Systemic inflammation and oxidative stress can contribute to blood brain barrier permeability and the ensuing neuro-inflammation, characteristic of Alzheimer’s disease. While large inter-individual variability exists, especially concerning disease pathogenesis, the IDDM hypothesis acknowledges primary causative factors which can be targeted for early diagnosis and/or for prevention of disease progression." @default.
• W2898879062 created "2018-11-09" @default.
• W2898879062 creator A5010148332 @default.
• W2898879062 creator A5061484661 @default.
• W2898879062 creator A5077370611 @default.
• W2898879062 date "2018-11-16" @default.
• W2898879062 modified "2023-09-26" @default.
• W2898879062 title "Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer’s Type Dementia" @default.
• W2898879062 cites W1141274631 @default.
• W2898879062 cites W128393251 @default.
• W2898879062 cites W145906557 @default.
• W2898879062 cites W1490861410 @default.
• W2898879062 cites W1507392760 @default.
• W2898879062 cites W1526611045 @default.
• W2898879062 cites W1539745633 @default.
• W2898879062 cites W1542215809 @default.
• W2898879062 cites W1558025472 @default.
• W2898879062 cites W1573348274 @default.
• W2898879062 cites W1584411124 @default.
• W2898879062 cites W1593684700 @default.
• W2898879062 cites W1594425991 @default.
• W2898879062 cites W1605886981 @default.
• W2898879062 cites W1607244686 @default.
• W2898879062 cites W1607614294 @default.
• W2898879062 cites W1690235847 @default.
• W2898879062 cites W1780479323 @default.
• W2898879062 cites W1785761853 @default.
• W2898879062 cites W1809070781 @default.
• W2898879062 cites W1825857774 @default.
• W2898879062 cites W183546090 @default.
• W2898879062 cites W1903888485 @default.
• W2898879062 cites W193380391 @default.
• W2898879062 cites W1949033386 @default.
• W2898879062 cites W1963507584 @default.
• W2898879062 cites W1968281015 @default.
• W2898879062 cites W1973891716 @default.
• W2898879062 cites W1974081986 @default.
• W2898879062 cites W1976936948 @default.
• W2898879062 cites W1982388837 @default.
• W2898879062 cites W1985292728 @default.
• W2898879062 cites W1988125422 @default.
• W2898879062 cites W1988210470 @default.
• W2898879062 cites W1989889539 @default.
• W2898879062 cites W1992529581 @default.
• W2898879062 cites W1992746042 @default.
• W2898879062 cites W1996561667 @default.
• W2898879062 cites W1998169884 @default.
• W2898879062 cites W1998355147 @default.
• W2898879062 cites W1998417732 @default.
• W2898879062 cites W1999173176 @default.
• W2898879062 cites W2000632630 @default.
• W2898879062 cites W2016271868 @default.
• W2898879062 cites W2018258513 @default.
• W2898879062 cites W2019055807 @default.
• W2898879062 cites W2021777993 @default.
• W2898879062 cites W2022619952 @default.
• W2898879062 cites W2028034405 @default.
• W2898879062 cites W2031240692 @default.
• W2898879062 cites W2035079086 @default.
• W2898879062 cites W2036488650 @default.
• W2898879062 cites W2041561421 @default.
• W2898879062 cites W2042948859 @default.
• W2898879062 cites W2044842166 @default.
• W2898879062 cites W2045825103 @default.
• W2898879062 cites W2054113864 @default.
• W2898879062 cites W2057075949 @default.
• W2898879062 cites W2058208662 @default.
• W2898879062 cites W2060976020 @default.
• W2898879062 cites W2063583344 @default.
• W2898879062 cites W2064722737 @default.
• W2898879062 cites W2066458453 @default.
• W2898879062 cites W2066901261 @default.
• W2898879062 cites W2067203120 @default.
• W2898879062 cites W2070400665 @default.
• W2898879062 cites W2071384955 @default.
• W2898879062 cites W2075575178 @default.
• W2898879062 cites W2078408808 @default.
• W2898879062 cites W2078556521 @default.
• W2898879062 cites W2079738433 @default.
• W2898879062 cites W2080946103 @default.
• W2898879062 cites W2082149083 @default.
• W2898879062 cites W2082429191 @default.
• W2898879062 cites W2084272059 @default.
• W2898879062 cites W2086548013 @default.
• W2898879062 cites W2087170622 @default.
• W2898879062 cites W2087595637 @default.
• W2898879062 cites W2087927857 @default.
• W2898879062 cites W2088453821 @default.
• W2898879062 cites W2090112204 @default.
• W2898879062 cites W2091351161 @default.
• W2898879062 cites W2093104438 @default.
• W2898879062 cites W2096410114 @default.
• W2898879062 cites W2098256708 @default.
• W2898879062 cites W2099157718 @default.
• W2898879062 cites W2099751992 @default.
• W2898879062 cites W2100746158 @default.
• W2898879062 cites W2103062509 @default.
• W2898879062 cites W2106960039 @default.
• W2898879062 cites W2107504607 @default.
• W2898879062 cites W2112325559 @default.

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