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- W289887930 endingPage "82" @default.
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- W289887930 abstract "Diabetes is on the rise in the United States and the rest of the world, and its complications are even more evident in the aging population. Among the most severe complications of diabetes are impaired circulation and wound healing. The former condition, together with peripheral neuropathy, contributes to an insensate, poorly vascularized lower extremity that is prone to the development of chronic wounds. Lack of sensation leads to aggravation of the injury, which can frequently lead to the spread of infection and the loss of all or part of the lower limb. The circulatory defects occur in both conducting vessels—which are prone to atherosclerosis—and the microcirculation, which shows signs of basement membrane thickening and diminished reparative capacity. Surgical intervention can sometimes alleviate the macrovascular defects, but grafting procedures cannot guarantee that tissue perfusion can be restored. With the exception of the retina, the poor growth of new capillary vessels in diabetes broadly diminishes the capacity to repair." @default.
- W289887930 created "2016-06-24" @default.
- W289887930 creator A5001159362 @default.
- W289887930 creator A5042901115 @default.
- W289887930 date "2007-11-05" @default.
- W289887930 modified "2023-10-18" @default.
- W289887930 title "The Wound-Healing Process" @default.
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- W289887930 doi "https://doi.org/10.1007/978-1-59745-075-1_4" @default.
- W289887930 hasPublicationYear "2007" @default.
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