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- W2898880229 abstract "Objectives: The long-term effects of concussion in youth remain poorly understood. The objective of this study was to determine the association between history of concussion and cerebral blood flow (CBF) in youth.Methods: A total of 53 children and adolescents with a history of concussion (n = 37) or orthopaedic injury (OI; n = 16) were considered. Measures included pseudo-continuous arterial spin labelling magnetic resonance imaging to quantify CBF, post-concussion symptoms, psychological symptoms, and cognitive testing.Results: Participants (mean age: 14.4 years, 95% CI = 13.8–15.4, range = 8–19) were on average 2.7 years (95% CI = 2.2–3.1) post-injury. Youth with a history of concussion had higher parent-reported physical, cognitive, anxiety, and depression symptoms than children with OI, but the groups did not differ on self-reported symptoms (post-concussive or psychological) or cognitive testing. Global CBF did not differ between groups. Regional CBF analyses suggested that youth with a history of concussion had hypoperfusion in posterior and inferior regions and hyperperfusion in anterior/frontal/temporal regions as compared to those with OI. However, neither global nor regional CBF were significantly associated with demographics, pre-injury functioning, number of concussions, time since injury, post-concussive symptoms, psychological symptoms, or cognitive abilities.Conclusions: Youth with a history of concussion demonstrate differences in regional CBF (not global CBF), but without clear clinical expression." @default.
- W2898880229 created "2018-11-09" @default.
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- W2898880229 date "2018-10-31" @default.
- W2898880229 modified "2023-10-06" @default.
- W2898880229 title "Cerebral blood flow in children and adolescents several years after concussion" @default.
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- W2898880229 doi "https://doi.org/10.1080/02699052.2018.1540798" @default.
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