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- W2898885622 abstract "Background: The involvement of NR4A1 orphan receptors activation in pre-lymphocytes, pro-lymphocytes and lymphocytes apoptosis is controversial, also when related to calcium fluxes. Aim: The goal of our study was represented by the characterization of NR4A1 activation-induced effects on pro-B cells apoptosis in the presence of ionomycin, a calcium overloading inducer. Methods: All cells batches were evaluated under contrast-phase microscopy, using an Eclipse TE-300 Nikon microscope with a 40x objective. The apoptotic cells number was expressed as a percentage of the total number of cells, taking into account their morphological appearance. Results: The treatment of pro-B cells with 5 mM ionomycin and 1 mM Ca2+ in culture medium for 24 hours induced a modest, but significant apoptosis as compared to control series, evidenced by morphological appearance. On the other side, the pro-B cells treated with 50 mM Cytosporone B for 24 hours, together with 5 mM ionomycin and 1 mM Ca2+ show a reduced grade of apoptosis as compared to solely ionomycin and calcium series. Conclusions: Thus, NR4A1 orphan receptor activation might reduce the apoptotic effects of calcium overload in pro-B cells, an intriguing effect which might be further researched." @default.
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- W2898885622 date "2015-09-30" @default.
- W2898885622 modified "2023-09-24" @default.
- W2898885622 title "NR4A1-ACTIVATED RECEPTORS ASSOCIATED WITH Ca2+ CYTOSOLIC INCREASE IS NOT INDUCING AUGMENTED APOPTOSIS IN PRO-B CELLS" @default.
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