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• W2898889497 abstract "INTRODUCTION: Childhood Asthma has emerged perhaps as the commonestchronic medical problem treated by pediatricians all over the world.what was originally thought to be a disorder affecting only adults hasemerged as a very significant problem affecting the child’s life styleand day to day activities including schooling, sports and recreation.The incidence of asthma is increasing alarmingly in the past fewdecades1.Because asthma is a complex and heterogenous disease withmany phenotypic expressions through the course of childhood, it ischallenging to characterize. First the clinical manifestations of asthmaare non specific and many children wheeze during the first few years oflife. But only a few of these children develop persistent wheezing andclinical asthma2. Approximately 60% are transient wheezes whooutgrow their disease by 5 years of age. DEFINITION OF ASTHMA: The manner in which asthma has been defined has changedsignificantly over time. ·1.In 1950’s asthma was defined as a disease characterized byairflow obstruction that could resolve spontaneously or followingtherapy3.2. In 1960’s asthma was viewed as an episodic disease in whichairflow obstruction was caused by bronchial hyperresponsiveness4.3. In 1970’s the concept of preventing bronchospasm andmanaging disease progression was considered. 4.In 1990’s asthma was redefined as a chronic inflammatorydisease characterized by reversible airflow obstruction andbronchial hyper responsiveness. AIM OF THE STUDY: 1. To assess the prevalence of specific co-morbid conditions like(a) Allergic rhinitis,(b) Sinusitis and(c) Gastroesophageal reflux disease in children with asthma2. Association of these conditions in relation to severity of asthma. DISCUSSION: AGE AND SEX DISTRIBUTION OF ASTHMA: Most of the children with asthma were in the age group of6-8 years, although they were more or less equally distributed.The male : female ratio is 1.22 : 1, although no statistical significancewas found. FAMILY HISTORY OF ASTHMA / ATOPY: The children with asthma with family History of Asthma / Atopywere 66 out of 159. The distribution of them among first degree andsecond degree relatives were 35 and 31 respectively. The relationshipof family History of asthma/atopy with different grades of asthma wasnot statistically significant. But several studies like A.Ten Brinke et al10., have shown thatpatients with frequent asthma exacerbations (Severe asthma) moreoften had family history of asthma/atopy which was statisticallysignificant. SEVERITY OF ASTHMA: The distribution of asthma was less in Grade IV (SeverePersistent) - 4.4 %. Several studies including Irwin et al11, that weredone in adult patients with asthma have shown more or less equaldistribution among different grades of asthma. CONCLUSION: 1. This study concludes that the prevalence of Allergic Rhinitis andsinusitis was greater in children with asthma.2. There is a higher prevalence of Allergic rhinitis and sinusitisamong moderate /severe asthma than mild group of childrenwith asthma, implicating that these factors could contribute to theseverity of asthma and its exacerbations.3. So all the children diagnosed as bronchial asthma, particularlymoderate persistent and severe persistent asthma should beevaluated for the presence of co-morbid conditions, which iftreated simultaneously will result in less asthma exacerbationswith a greater improvement in their quality of life includingschooling, sports and recreation." @default.
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• W2898889497 date "2007-03-01" @default.
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• W2898889497 title "Prevalence of Comorbid Conditions in Relation to Severity of Asthma" @default.
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