FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898894652> ?p ?o ?g. }

• W2898894652 endingPage "16" @default.
• W2898894652 startingPage "1" @default.
• W2898894652 abstract "Neurodegenerative disease is the umbrella term which refers to a range of clinical conditions causing degeneration of neurons within the central nervous system leading to loss of brain function and eventual death. The most prevalent of these is Alzheimer's disease (AD), which affects approximately 50 million people worldwide and is predicted to reach 75 million by 2030. Neurodegenerative diseases can only be fully diagnosed at post mortem by neuropathological assessment of the type and distribution of protein deposits which characterise each different condition, but there is a clear role for imaging technologies in aiding patient diagnoses in life. Magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques have been applied to study these conditions for many years. In this review, we consider the range of MR-based measurements and describe the findings in AD, but also contrast these with the second most common dementia, dementia with Lewy bodies (DLB). The most definitive observation is the major structural brain changes seen in AD using conventional T1-weighted (T1w) MRI, where medial temporal lobe structures are notably atrophied in most symptomatic patients with AD, but often preserved in DLB. Indeed these findings are sufficiently robust to have been incorporated into clinical diagnostic criteria. Diffusion tensor imaging (DTI) reveals widespread changes in tissue microstructure, with increased mean diffusivity and decreased fractional anisotropy reflecting the degeneration of the white matter structures. There are suggestions that there are subtle differences between AD and DLB populations. At the metabolic level, atrophy-corrected MRS demonstrates reduced density of healthy neurons in brain areas with altered perfusion and in regions known to show higher deposits of pathogenic proteins. As studies have moved from patients with advanced disease and clear dysfunction to patients with earlier presentation such as with mild cognitive impairment (MCI), which in some represents the first signs of their ensuing dementia, the ability of MRI to detect differences has been weaker and further work is still required, ideally in much larger cohorts than previously studied. The vast majority of imaging research in dementia populations has been univariate with respect to the MR-derived parameters considered. To date, none of these measurements has uniquely replicated the patterns of tissue involvement seen by neuropathology, and the ability of MR techniques to deliver a non-invasive diagnosis eludes us. Future opportunities may lie in combining MR and nuclear medicine approaches (position emission tomography, PET) to provide a more complete view of structural and metabolic changes. Such developments will require multi-variate analyses, possibly combined with artificial intelligence or deep learning algorithms, to enhance our ability to combine the array of image-derived information, genetic, gender and lifestyle factors." @default.
• W2898894652 created "2018-11-09" @default.
• W2898894652 creator A5082915677 @default.
• W2898894652 date "2018-10-01" @default.
• W2898894652 modified "2023-10-18" @default.
• W2898894652 title "MR approaches in neurodegenerative disorders" @default.
• W2898894652 cites W130563365 @default.
• W2898894652 cites W1535235699 @default.
• W2898894652 cites W1552654146 @default.
• W2898894652 cites W1561232794 @default.
• W2898894652 cites W1644155731 @default.
• W2898894652 cites W1663551020 @default.
• W2898894652 cites W1897859562 @default.
• W2898894652 cites W1945925007 @default.
• W2898894652 cites W1967069915 @default.
• W2898894652 cites W1967823816 @default.
• W2898894652 cites W1971640012 @default.
• W2898894652 cites W1972188024 @default.
• W2898894652 cites W1973648620 @default.
• W2898894652 cites W1974239573 @default.
• W2898894652 cites W1979876709 @default.
• W2898894652 cites W1983107913 @default.
• W2898894652 cites W1983731103 @default.
• W2898894652 cites W1984243897 @default.
• W2898894652 cites W1986245961 @default.
• W2898894652 cites W1988693860 @default.
• W2898894652 cites W1989128216 @default.
• W2898894652 cites W1992515424 @default.
• W2898894652 cites W1992816826 @default.
• W2898894652 cites W1994839798 @default.
• W2898894652 cites W1998729594 @default.
• W2898894652 cites W2000245563 @default.
• W2898894652 cites W2001905605 @default.
• W2898894652 cites W2002081170 @default.
• W2898894652 cites W2002385808 @default.
• W2898894652 cites W2008762660 @default.
• W2898894652 cites W2009739635 @default.
• W2898894652 cites W2012932267 @default.
• W2898894652 cites W2019305871 @default.
• W2898894652 cites W2022178541 @default.
• W2898894652 cites W2023798788 @default.
• W2898894652 cites W2024062346 @default.
• W2898894652 cites W2024480069 @default.
• W2898894652 cites W2025555343 @default.
• W2898894652 cites W2028529684 @default.
• W2898894652 cites W2030309279 @default.
• W2898894652 cites W2030885292 @default.
• W2898894652 cites W2036550078 @default.
• W2898894652 cites W2039562991 @default.
• W2898894652 cites W2040976452 @default.
• W2898894652 cites W2041676874 @default.
• W2898894652 cites W2046429594 @default.
• W2898894652 cites W2046529900 @default.
• W2898894652 cites W2048856588 @default.
• W2898894652 cites W2051974247 @default.
• W2898894652 cites W2052192539 @default.
• W2898894652 cites W2052742260 @default.
• W2898894652 cites W2054163710 @default.
• W2898894652 cites W2055635555 @default.
• W2898894652 cites W2063225300 @default.
• W2898894652 cites W2064243689 @default.
• W2898894652 cites W2069100635 @default.
• W2898894652 cites W2070267512 @default.
• W2898894652 cites W2072023975 @default.
• W2898894652 cites W2073449985 @default.
• W2898894652 cites W2076902012 @default.
• W2898894652 cites W2077822545 @default.
• W2898894652 cites W2077924486 @default.
• W2898894652 cites W2078096700 @default.
• W2898894652 cites W2078920987 @default.
• W2898894652 cites W2082505510 @default.
• W2898894652 cites W2084761689 @default.
• W2898894652 cites W2084787525 @default.
• W2898894652 cites W2086136360 @default.
• W2898894652 cites W2087446528 @default.
• W2898894652 cites W2088157069 @default.
• W2898894652 cites W2093650784 @default.
• W2898894652 cites W2094854824 @default.
• W2898894652 cites W2096817071 @default.
• W2898894652 cites W2100651338 @default.
• W2898894652 cites W2100875841 @default.
• W2898894652 cites W2101421921 @default.
• W2898894652 cites W2101563929 @default.
• W2898894652 cites W2101861019 @default.
• W2898894652 cites W2102118295 @default.
• W2898894652 cites W2103105772 @default.
• W2898894652 cites W2111240150 @default.
• W2898894652 cites W2115424422 @default.
• W2898894652 cites W2118521681 @default.
• W2898894652 cites W2119502028 @default.
• W2898894652 cites W2121597504 @default.
• W2898894652 cites W2122236448 @default.
• W2898894652 cites W2123261378 @default.
• W2898894652 cites W2126587011 @default.
• W2898894652 cites W2126777896 @default.
• W2898894652 cites W2128106262 @default.
• W2898894652 cites W2128776571 @default.
• W2898894652 cites W2129006179 @default.

• next