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• W2898894785 abstract "The cardiac excitation-contraction coupling is the cellular process through which the heart absolves its blood pumping function, and it is directly affected when cardiac pathologies occur. Cardiomyocytes are the functional units in which this complex biomolecular process takes place: they can be represented as a two-stage electro-chemo and chemo-mechanical transducer, along which each stage can be probed and monitored via appropriate micro/nanotechnology-based tools. Atomic force microscopy (AFM), with its unique nanoresolved force sensitivity and versatile modes of extracting sample properties, can represent a key instrument to study time-dependent heart mechanics and topography at the single cell level. In this work, we show how the integrative possibilities of AFM allowed us to implement an in vitro system which can monitor cardiac electrophysiology, intracellular calcium dynamics, and single cell mechanics. We believe this single cell-sensitive and integrated system will unlock improved, fast, and reliable cardiac in vitro tests in the future." @default.
• W2898894785 created "2018-11-09" @default.
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• W2898894785 date "2018-10-30" @default.
• W2898894785 modified "2023-10-09" @default.
• W2898894785 title "Simultaneous AFM Investigation of the Single Cardiomyocyte Electro-Chemo-Mechanics During Excitation-Contraction Coupling" @default.
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• W2898894785 doi "https://doi.org/10.1007/978-1-4939-8894-5_21" @default.
• W2898894785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30374879" @default.
• W2898894785 hasPublicationYear "2018" @default.
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