FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898897253> ?p ?o ?g. }

• W2898897253 endingPage "39" @default.
• W2898897253 startingPage "31" @default.
• W2898897253 abstract "Targeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25–85% of patients treated by epidermal growth factor receptor and mitogen-activated protein kinase kinase inhibitors. BRAF inhibitors mostly induce secondary skin tumors, squamous cell carcinoma and keratoacanthomas, changes in pre-existing pigmented lesions, as well as hand-foot skin reactions and maculopapular hypersensitivity-like rash. Immune checkpoint inhibitors (ICIs) most frequently induce nonspecific maculopapular rash, but also eczema-like or psoriatic lesions, lichenoid dermatitis, xerosis, and pruritus. Of the oral mucosal toxicities observed with targeted therapies, oral mucositis is the most frequent with mammalian target of rapamycin (mTOR) inhibitors, followed by stomatitis associated to multikinase angiogenesis and HER inhibitors, geographic tongue, oral hyperkeratotic lesions, lichenoid reactions, and hyperpigmentation. ICIs typically induce oral lichenoid reactions and xerostomia. Targeted therapies and endocrine therapy also commonly induce alopecia, although this is still underreported with the latter. Finally, targeted therapies may damage nail folds, with paronychia and periungual pyogenic granuloma distinct from chemotherapy-induced lesions. Mild onycholysis, brittle nails, and a slower nail growth rate may also be observed. Targeted therapies and immunotherapies often profoundly diminish patients’ quality of life, which impacts treatment outcomes. Close collaboration between dermatologists and oncologists is therefore essential." @default.
• W2898897253 created "2018-11-09" @default.
• W2898897253 creator A5002599922 @default.
• W2898897253 creator A5082390042 @default.
• W2898897253 date "2018-10-30" @default.
• W2898897253 modified "2023-10-14" @default.
• W2898897253 title "Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails" @default.
• W2898897253 cites W1500908316 @default.
• W2898897253 cites W1585093095 @default.
• W2898897253 cites W1805836286 @default.
• W2898897253 cites W1827097565 @default.
• W2898897253 cites W1897773793 @default.
• W2898897253 cites W190066503 @default.
• W2898897253 cites W1913801405 @default.
• W2898897253 cites W1974317256 @default.
• W2898897253 cites W1977150650 @default.
• W2898897253 cites W1986493129 @default.
• W2898897253 cites W1986803564 @default.
• W2898897253 cites W1990719422 @default.
• W2898897253 cites W1993668182 @default.
• W2898897253 cites W2004181803 @default.
• W2898897253 cites W2011513069 @default.
• W2898897253 cites W2024589037 @default.
• W2898897253 cites W2041731270 @default.
• W2898897253 cites W2051165598 @default.
• W2898897253 cites W2051497446 @default.
• W2898897253 cites W2060887776 @default.
• W2898897253 cites W2065621410 @default.
• W2898897253 cites W2076435256 @default.
• W2898897253 cites W2081995364 @default.
• W2898897253 cites W2097762752 @default.
• W2898897253 cites W2120848693 @default.
• W2898897253 cites W2121314233 @default.
• W2898897253 cites W2121545342 @default.
• W2898897253 cites W2125278359 @default.
• W2898897253 cites W2128542677 @default.
• W2898897253 cites W2136474966 @default.
• W2898897253 cites W2138297714 @default.
• W2898897253 cites W2138941169 @default.
• W2898897253 cites W2141051403 @default.
• W2898897253 cites W2149050045 @default.
• W2898897253 cites W2153942285 @default.
• W2898897253 cites W2155461614 @default.
• W2898897253 cites W2156078931 @default.
• W2898897253 cites W2160344439 @default.
• W2898897253 cites W2160766792 @default.
• W2898897253 cites W2164613605 @default.
• W2898897253 cites W2166395861 @default.
• W2898897253 cites W2167178083 @default.
• W2898897253 cites W2179179825 @default.
• W2898897253 cites W2207106648 @default.
• W2898897253 cites W2229841771 @default.
• W2898897253 cites W2237781459 @default.
• W2898897253 cites W2274868168 @default.
• W2898897253 cites W2288531107 @default.
• W2898897253 cites W2289841322 @default.
• W2898897253 cites W2302072645 @default.
• W2898897253 cites W2329871425 @default.
• W2898897253 cites W2343144688 @default.
• W2898897253 cites W2409547711 @default.
• W2898897253 cites W2464708391 @default.
• W2898897253 cites W2484060194 @default.
• W2898897253 cites W2491982852 @default.
• W2898897253 cites W2507729480 @default.
• W2898897253 cites W2531852397 @default.
• W2898897253 cites W2560268030 @default.
• W2898897253 cites W2590907207 @default.
• W2898897253 cites W2595794139 @default.
• W2898897253 cites W2606245083 @default.
• W2898897253 cites W2606429310 @default.
• W2898897253 cites W2618086539 @default.
• W2898897253 cites W2742574328 @default.
• W2898897253 cites W2749656666 @default.
• W2898897253 cites W2755064765 @default.
• W2898897253 cites W2768071339 @default.
• W2898897253 cites W2797884904 @default.
• W2898897253 doi "https://doi.org/10.1007/s40257-018-0384-3" @default.
• W2898897253 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6244569" @default.
• W2898897253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30374901" @default.
• W2898897253 hasPublicationYear "2018" @default.
• W2898897253 type Work @default.
• W2898897253 sameAs 2898897253 @default.
• W2898897253 citedByCount "181" @default.
• W2898897253 countsByYear W28988972532018 @default.
• W2898897253 countsByYear W28988972532019 @default.
• W2898897253 countsByYear W28988972532020 @default.
• W2898897253 countsByYear W28988972532021 @default.
• W2898897253 countsByYear W28988972532022 @default.
• W2898897253 countsByYear W28988972532023 @default.
• W2898897253 crossrefType "journal-article" @default.
• W2898897253 hasAuthorship W2898897253A5002599922 @default.
• W2898897253 hasAuthorship W2898897253A5082390042 @default.
• W2898897253 hasBestOaLocation W28988972531 @default.
• W2898897253 hasConcept C126322002 @default.
• W2898897253 hasConcept C142724271 @default.
• W2898897253 hasConcept C16005928 @default.
• W2898897253 hasConcept C2779409057 @default.
• W2898897253 hasConcept C500440147 @default.

• next