FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898897599> ?p ?o ?g. }

• W2898897599 endingPage "9" @default.
• W2898897599 startingPage "1" @default.
• W2898897599 abstract "Abnormal angiogenesis plays a major role in the development of early stage diabetic nephropathy. Vascular endothelial growth factor (VEGF) is a classical proangiogenic factor that regulates abnormal glomerular angiogenesis linked to glomerular hypertrophy in the early stage of diabetic nephropathy. Leucine-rich α-2-glycoprotein-1 (LRG1) was recently reported as a novel proangiogenic factor that is expressed in endothelial cells and promotes angiogenesis by modulating the transforming growth factor-β signaling pathway. However, the pathophysiology of LRG1 in diabetic nephropathy remains largely unknown. In the present study, we investigated intrarenal expression of the novel proangiogenic factor LRG1 in diabetic db/db mice by immunohistochemistry and a laser capture microdissection method during the development of diabetic nephropathy. We hypothesized that glomerular LRG1 expression is increased earlier than VEGF expression under conditions of pathological angiogenesis in the early stage of diabetic nephropathy. Thus, we compared glomerular expression of VEGF and LRG1 in diabetic db/db mice at 16 and 24 weeks of age. At 16 weeks, diabetic db/db mice exhibited glomerular hypertrophy with abnormal angiogenesis characterized by endothelial cell proliferation, which was concomitant with an increase in LRG1 expression of glomerular endothelial cells. However, glomerular VEGF expression was not increased at this early stage. At 24 weeks, the features of early diabetic nephropathy in db/db mice had developed further, along with further enhanced glomerular LRG1 expression. At this late stage, glomerular VEGF and fibrosis-related-gene expression was also significantly increased compared with nondiabetic db/m mice. These results suggest that LRG1 plays a pivotal role in the initial development of diabetic nephropathy by promoting abnormal angiogenesis, thereby suggesting that LRG1 is a potential preemptive therapeutic target of diabetic nephropathy." @default.
• W2898897599 created "2018-11-09" @default.
• W2898897599 creator A5004828449 @default.
• W2898897599 creator A5007576993 @default.
• W2898897599 creator A5020782423 @default.
• W2898897599 creator A5021425190 @default.
• W2898897599 creator A5024617021 @default.
• W2898897599 creator A5028819689 @default.
• W2898897599 creator A5043672301 @default.
• W2898897599 creator A5044044075 @default.
• W2898897599 creator A5047613165 @default.
• W2898897599 creator A5049659161 @default.
• W2898897599 creator A5063566174 @default.
• W2898897599 creator A5065349837 @default.
• W2898897599 creator A5065613884 @default.
• W2898897599 creator A5071575645 @default.
• W2898897599 creator A5080181199 @default.
• W2898897599 creator A5081793444 @default.
• W2898897599 date "2018-11-01" @default.
• W2898897599 modified "2023-10-13" @default.
• W2898897599 title "Early Enhanced Leucine-Rich <i>α</i>-2-Glycoprotein-1 Expression in Glomerular Endothelial Cells of Type 2 Diabetic Nephropathy Model Mice" @default.
• W2898897599 cites W1965175129 @default.
• W2898897599 cites W1971119095 @default.
• W2898897599 cites W1988613013 @default.
• W2898897599 cites W2012403942 @default.
• W2898897599 cites W2013459541 @default.
• W2898897599 cites W2016865792 @default.
• W2898897599 cites W2021461358 @default.
• W2898897599 cites W2041089635 @default.
• W2898897599 cites W2052825248 @default.
• W2898897599 cites W2062361442 @default.
• W2898897599 cites W2065059716 @default.
• W2898897599 cites W2087187911 @default.
• W2898897599 cites W2089713276 @default.
• W2898897599 cites W2120953129 @default.
• W2898897599 cites W2121695887 @default.
• W2898897599 cites W2126287228 @default.
• W2898897599 cites W2135068186 @default.
• W2898897599 cites W2135505642 @default.
• W2898897599 cites W2146713188 @default.
• W2898897599 cites W2165325650 @default.
• W2898897599 cites W2165386872 @default.
• W2898897599 cites W2165843485 @default.
• W2898897599 cites W2167528781 @default.
• W2898897599 cites W2175101947 @default.
• W2898897599 cites W2288200855 @default.
• W2898897599 cites W2302244837 @default.
• W2898897599 cites W2412764356 @default.
• W2898897599 cites W2565348728 @default.
• W2898897599 cites W2570149818 @default.
• W2898897599 cites W2593781826 @default.
• W2898897599 cites W2741748339 @default.
• W2898897599 cites W2741966086 @default.
• W2898897599 cites W2766536598 @default.
• W2898897599 cites W2783106036 @default.
• W2898897599 cites W2806528763 @default.
• W2898897599 cites W4246561197 @default.
• W2898897599 doi "https://doi.org/10.1155/2018/2817045" @default.
• W2898897599 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6236974" @default.
• W2898897599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30515388" @default.
• W2898897599 hasPublicationYear "2018" @default.
• W2898897599 type Work @default.
• W2898897599 sameAs 2898897599 @default.
• W2898897599 citedByCount "16" @default.
• W2898897599 countsByYear W28988975992020 @default.
• W2898897599 countsByYear W28988975992021 @default.
• W2898897599 countsByYear W28988975992022 @default.
• W2898897599 countsByYear W28988975992023 @default.
• W2898897599 crossrefType "journal-article" @default.
• W2898897599 hasAuthorship W2898897599A5004828449 @default.
• W2898897599 hasAuthorship W2898897599A5007576993 @default.
• W2898897599 hasAuthorship W2898897599A5020782423 @default.
• W2898897599 hasAuthorship W2898897599A5021425190 @default.
• W2898897599 hasAuthorship W2898897599A5024617021 @default.
• W2898897599 hasAuthorship W2898897599A5028819689 @default.
• W2898897599 hasAuthorship W2898897599A5043672301 @default.
• W2898897599 hasAuthorship W2898897599A5044044075 @default.
• W2898897599 hasAuthorship W2898897599A5047613165 @default.
• W2898897599 hasAuthorship W2898897599A5049659161 @default.
• W2898897599 hasAuthorship W2898897599A5063566174 @default.
• W2898897599 hasAuthorship W2898897599A5065349837 @default.
• W2898897599 hasAuthorship W2898897599A5065613884 @default.
• W2898897599 hasAuthorship W2898897599A5071575645 @default.
• W2898897599 hasAuthorship W2898897599A5080181199 @default.
• W2898897599 hasAuthorship W2898897599A5081793444 @default.
• W2898897599 hasBestOaLocation W28988975991 @default.
• W2898897599 hasConcept C126322002 @default.
• W2898897599 hasConcept C134018914 @default.
• W2898897599 hasConcept C167734588 @default.
• W2898897599 hasConcept C2777025900 @default.
• W2898897599 hasConcept C2779922275 @default.
• W2898897599 hasConcept C2780394083 @default.
• W2898897599 hasConcept C2781184683 @default.
• W2898897599 hasConcept C555293320 @default.
• W2898897599 hasConcept C71924100 @default.
• W2898897599 hasConceptScore W2898897599C126322002 @default.
• W2898897599 hasConceptScore W2898897599C134018914 @default.
• W2898897599 hasConceptScore W2898897599C167734588 @default.

• next