Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898897840> ?p ?o ?g. }
- W2898897840 abstract "Presynaptic neuronal activity requires the localization of thousands of proteins that are typically synthesized in the soma and transported to nerve terminals. Local translation for some dendritic proteins occurs, but local translation in mammalian presynaptic nerve terminals is difficult to demonstrate. Here, we show an essential ribosomal component, 5.8S rRNA, at a glutamatergic nerve terminal in the mammalian brain. We also show active translation in nerve terminals, in situ, in brain slices demonstrating ongoing presynaptic protein synthesis in the mammalian brain. Shortly after inhibiting translation, the presynaptic terminal exhibits increased spontaneous release, an increased paired pulse ratio, an increased vesicle replenishment rate during stimulation trains, and a reduced initial probability of release. The rise and decay rates of postsynaptic responses were not affected. We conclude that ongoing protein synthesis can limit excessive vesicle release which reduces the vesicle replenishment rate, thus conserving the energy required for maintaining synaptic transmission." @default.
- W2898897840 created "2018-11-09" @default.
- W2898897840 creator A5012909852 @default.
- W2898897840 creator A5038582823 @default.
- W2898897840 creator A5050836755 @default.
- W2898897840 creator A5071787667 @default.
- W2898897840 date "2018-10-30" @default.
- W2898897840 modified "2023-09-29" @default.
- W2898897840 title "Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition" @default.
- W2898897840 cites W1664184517 @default.
- W2898897840 cites W1678534475 @default.
- W2898897840 cites W1707320767 @default.
- W2898897840 cites W1837990406 @default.
- W2898897840 cites W1877594537 @default.
- W2898897840 cites W1937556537 @default.
- W2898897840 cites W1966194317 @default.
- W2898897840 cites W1966355679 @default.
- W2898897840 cites W1967033814 @default.
- W2898897840 cites W1967646152 @default.
- W2898897840 cites W1974741729 @default.
- W2898897840 cites W1975727393 @default.
- W2898897840 cites W1981097208 @default.
- W2898897840 cites W1984150813 @default.
- W2898897840 cites W1984447462 @default.
- W2898897840 cites W1985064858 @default.
- W2898897840 cites W1987935829 @default.
- W2898897840 cites W1990740805 @default.
- W2898897840 cites W2000874341 @default.
- W2898897840 cites W2003674836 @default.
- W2898897840 cites W2003748392 @default.
- W2898897840 cites W2007489401 @default.
- W2898897840 cites W2010905290 @default.
- W2898897840 cites W2011356607 @default.
- W2898897840 cites W2015600303 @default.
- W2898897840 cites W2018404810 @default.
- W2898897840 cites W2025813409 @default.
- W2898897840 cites W2027195402 @default.
- W2898897840 cites W2031779883 @default.
- W2898897840 cites W2033206515 @default.
- W2898897840 cites W2035205069 @default.
- W2898897840 cites W2038134981 @default.
- W2898897840 cites W2039919932 @default.
- W2898897840 cites W2040023740 @default.
- W2898897840 cites W2040890514 @default.
- W2898897840 cites W2043132624 @default.
- W2898897840 cites W2044420805 @default.
- W2898897840 cites W2047569375 @default.
- W2898897840 cites W2060412325 @default.
- W2898897840 cites W2061874570 @default.
- W2898897840 cites W2065643323 @default.
- W2898897840 cites W2065786892 @default.
- W2898897840 cites W2068105241 @default.
- W2898897840 cites W2071474610 @default.
- W2898897840 cites W2072152524 @default.
- W2898897840 cites W2072816770 @default.
- W2898897840 cites W2075437459 @default.
- W2898897840 cites W2079607057 @default.
- W2898897840 cites W2079838847 @default.
- W2898897840 cites W2079896411 @default.
- W2898897840 cites W2083279393 @default.
- W2898897840 cites W2090661905 @default.
- W2898897840 cites W2092617299 @default.
- W2898897840 cites W2095325838 @default.
- W2898897840 cites W2096681544 @default.
- W2898897840 cites W2098925729 @default.
- W2898897840 cites W2103450794 @default.
- W2898897840 cites W2105172681 @default.
- W2898897840 cites W2106858079 @default.
- W2898897840 cites W2124278680 @default.
- W2898897840 cites W2125752525 @default.
- W2898897840 cites W2134590664 @default.
- W2898897840 cites W2140563438 @default.
- W2898897840 cites W2143418370 @default.
- W2898897840 cites W2161365864 @default.
- W2898897840 cites W2161451120 @default.
- W2898897840 cites W2181711396 @default.
- W2898897840 cites W2261583454 @default.
- W2898897840 cites W2296069419 @default.
- W2898897840 cites W2345128307 @default.
- W2898897840 cites W2512007269 @default.
- W2898897840 cites W2524977785 @default.
- W2898897840 cites W2536391716 @default.
- W2898897840 cites W2536806087 @default.
- W2898897840 cites W2539335834 @default.
- W2898897840 cites W2575996993 @default.
- W2898897840 cites W2580291401 @default.
- W2898897840 cites W2605892792 @default.
- W2898897840 cites W2615441096 @default.
- W2898897840 cites W2759929715 @default.
- W2898897840 doi "https://doi.org/10.7554/elife.36697" @default.
- W2898897840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6231766" @default.
- W2898897840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30375975" @default.
- W2898897840 hasPublicationYear "2018" @default.
- W2898897840 type Work @default.
- W2898897840 sameAs 2898897840 @default.
- W2898897840 citedByCount "44" @default.
- W2898897840 countsByYear W28988978402018 @default.
- W2898897840 countsByYear W28988978402019 @default.
- W2898897840 countsByYear W28988978402020 @default.
- W2898897840 countsByYear W28988978402021 @default.