Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898898178> ?p ?o ?g. }
- W2898898178 abstract "Pregnancy establishment in cattle is contingent on conceptus elongation-a fundamental developmental event coinciding with the time during which most pregnancies fail. Elongation in vivo is directly driven by uterine secretions, indirectly influenced by systemic progesterone concentrations, and has yet to be recapitulated in vitro. To better understand the microenvironment evolved to facilitate this phenomenon, the amino acid and carbohydrate composition of uterine fluid was interrogated using high-throughput metabolomics on days 12, 13, and 14 of the estrous cycle from heifers with normal and high circulating progesterone. A total of 99 biochemicals (79 amino acids and 20 carbohydrates) were consistently identified, of which 31 showed a day by progesterone interaction. Fructose and mannitol/sorbitol did not exhibit a day by progesterone interaction, but displayed the greatest individual fluctuations (P ≤ 0.05) with respective fold increases of 18.39 and 28.53 in high vs normal progesterone heifers on day 12, and increases by 10.70-fold and 14.85-fold in the uterine fluid of normal progesterone animals on day 14 vs day 12. Moreover, enrichment analyses revealed that the phenylalanine, glutathione, polyamine, and arginine metabolic pathways were among the most affected by day and progesterone. In conclusion, progesterone had a largely stabilizing effect on amino acid flux, and identified biochemicals of likely importance to conceptus elongation initiation include arginine, fructose, glutamate, and mannitol/sorbitol." @default.
- W2898898178 created "2018-11-09" @default.
- W2898898178 creator A5027387872 @default.
- W2898898178 creator A5029896931 @default.
- W2898898178 creator A5049365258 @default.
- W2898898178 creator A5062630916 @default.
- W2898898178 creator A5070406270 @default.
- W2898898178 creator A5074537992 @default.
- W2898898178 date "2018-11-01" @default.
- W2898898178 modified "2023-10-15" @default.
- W2898898178 title "Biochemical characterization of progesterone-induced alterations in bovine uterine fluid amino acid and carbohydrate composition during the conceptus elongation window†" @default.
- W2898898178 cites W1418609983 @default.
- W2898898178 cites W1476194286 @default.
- W2898898178 cites W1975041988 @default.
- W2898898178 cites W1976610284 @default.
- W2898898178 cites W1980270094 @default.
- W2898898178 cites W1982788342 @default.
- W2898898178 cites W1984750471 @default.
- W2898898178 cites W1985236717 @default.
- W2898898178 cites W1985748545 @default.
- W2898898178 cites W1997119504 @default.
- W2898898178 cites W2003456695 @default.
- W2898898178 cites W2003467497 @default.
- W2898898178 cites W2008541096 @default.
- W2898898178 cites W2016465427 @default.
- W2898898178 cites W2017861034 @default.
- W2898898178 cites W2021963506 @default.
- W2898898178 cites W2023206550 @default.
- W2898898178 cites W2024817368 @default.
- W2898898178 cites W2024925103 @default.
- W2898898178 cites W2032159137 @default.
- W2898898178 cites W2032656879 @default.
- W2898898178 cites W2034847206 @default.
- W2898898178 cites W2035045680 @default.
- W2898898178 cites W2040136288 @default.
- W2898898178 cites W2043784228 @default.
- W2898898178 cites W2045120449 @default.
- W2898898178 cites W2051050360 @default.
- W2898898178 cites W2061915055 @default.
- W2898898178 cites W2067510355 @default.
- W2898898178 cites W2086694502 @default.
- W2898898178 cites W2087285715 @default.
- W2898898178 cites W2092010029 @default.
- W2898898178 cites W2095360746 @default.
- W2898898178 cites W2097357943 @default.
- W2898898178 cites W2099087059 @default.
- W2898898178 cites W2099828717 @default.
- W2898898178 cites W2100555516 @default.
- W2898898178 cites W2100682893 @default.
- W2898898178 cites W2104158422 @default.
- W2898898178 cites W2105108625 @default.
- W2898898178 cites W2105169496 @default.
- W2898898178 cites W2106610882 @default.
- W2898898178 cites W2108184608 @default.
- W2898898178 cites W2110752569 @default.
- W2898898178 cites W2114788769 @default.
- W2898898178 cites W2115651516 @default.
- W2898898178 cites W2118074213 @default.
- W2898898178 cites W2118748113 @default.
- W2898898178 cites W2119715474 @default.
- W2898898178 cites W2127542959 @default.
- W2898898178 cites W2128890381 @default.
- W2898898178 cites W2129097213 @default.
- W2898898178 cites W2129644933 @default.
- W2898898178 cites W2130392841 @default.
- W2898898178 cites W2130516623 @default.
- W2898898178 cites W2133642304 @default.
- W2898898178 cites W2133684121 @default.
- W2898898178 cites W2134322174 @default.
- W2898898178 cites W2134400556 @default.
- W2898898178 cites W2136960342 @default.
- W2898898178 cites W2138560227 @default.
- W2898898178 cites W2146883159 @default.
- W2898898178 cites W2150818194 @default.
- W2898898178 cites W2151219341 @default.
- W2898898178 cites W2152502075 @default.
- W2898898178 cites W2153799900 @default.
- W2898898178 cites W2157931113 @default.
- W2898898178 cites W2158280028 @default.
- W2898898178 cites W2159922117 @default.
- W2898898178 cites W2162790428 @default.
- W2898898178 cites W2163356262 @default.
- W2898898178 cites W2164445825 @default.
- W2898898178 cites W2210327828 @default.
- W2898898178 cites W2293274576 @default.
- W2898898178 cites W2337665072 @default.
- W2898898178 cites W2409079259 @default.
- W2898898178 cites W2466701427 @default.
- W2898898178 cites W2500518630 @default.
- W2898898178 cites W2518379041 @default.
- W2898898178 cites W2550532892 @default.
- W2898898178 cites W2554400146 @default.
- W2898898178 cites W2558895442 @default.
- W2898898178 cites W2593341513 @default.
- W2898898178 cites W2624698324 @default.
- W2898898178 cites W2745671033 @default.
- W2898898178 cites W2751496182 @default.
- W2898898178 cites W2803378479 @default.
- W2898898178 cites W2893506664 @default.
- W2898898178 cites W2608603876 @default.