FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898903301> ?p ?o ?g. }

• W2898903301 endingPage "70" @default.
• W2898903301 startingPage "60" @default.
• W2898903301 abstract "Dicyclohexyl phthalate (DCHP) is a phthalate plasticizer with a ring structure in the alcohol moiety. The objective to the current study was to determine the effects of DCHP on Leydig cell regeneration in the adult rat-testis. Adult male Sprague Dawley rats received intraperitoneally an injection of ethane dimethane sulfone (EDS) to eliminate all Leydig cells in the testis and then were divided into 4 groups of 0 (control), 10, 100, and 1000 mg/kg/day DCHP. Rats were gavaged either vehicle (corn oil, control) or DCHP from post-EDS day 7 to day 21 and 28. On post-EDS day 21 and day 28, rats were euthanized and serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) levels were measured, and Leydig cell number, cell size, gene, and protein expression were evaluated. During the course of exposure, DCHP did not cause the general toxicity to rats. On post-EDS day 21, DCHP significantly increased serum testosterone level at 10 and 100 mg/kg and increased Leydig cell number at 10 mg/kg via stimulating their mitosis. On post-EDS day 28, DCHP lowered serum testosterone levels and Leydig cell number at 1000 mg/kg. DCHP dose-dependently down-regulated the expression of many Leydig cell genes (Lhcgr, Scarb1, Star, Cyp11a1, Hsd3b1, Cyp17a1, Hsd17b3, Hsd11b1, and Insl3) and their proteins, especially at 1000 mg/kg. DCHP also lowered the pAKT1/AKT1 and pERK1/2/ERK1/2 ratios. In conclusion, DCHP at low doses (10 and 100 mg/kg) increased Leydig cell number during the initial regeneration and inhibited Leydig cell regeneration during the course of its exposure." @default.
• W2898903301 created "2018-11-09" @default.
• W2898903301 creator A5001693600 @default.
• W2898903301 creator A5005589098 @default.
• W2898903301 creator A5006256505 @default.
• W2898903301 creator A5014039664 @default.
• W2898903301 creator A5034480243 @default.
• W2898903301 creator A5060410353 @default.
• W2898903301 creator A5060598412 @default.
• W2898903301 creator A5071319862 @default.
• W2898903301 creator A5077937235 @default.
• W2898903301 creator A5088772562 @default.
• W2898903301 creator A5091243949 @default.
• W2898903301 date "2019-01-01" @default.
• W2898903301 modified "2023-09-23" @default.
• W2898903301 title "Dicyclohexyl phthalate blocks Leydig cell regeneration in adult rat testis" @default.
• W2898903301 cites W1795916275 @default.
• W2898903301 cites W1901329129 @default.
• W2898903301 cites W1963609106 @default.
• W2898903301 cites W1974928968 @default.
• W2898903301 cites W1983300755 @default.
• W2898903301 cites W1999543886 @default.
• W2898903301 cites W2000609399 @default.
• W2898903301 cites W2018447503 @default.
• W2898903301 cites W2018663321 @default.
• W2898903301 cites W2020884425 @default.
• W2898903301 cites W2020949449 @default.
• W2898903301 cites W2023083732 @default.
• W2898903301 cites W2027215921 @default.
• W2898903301 cites W2029781499 @default.
• W2898903301 cites W2041846642 @default.
• W2898903301 cites W2043226290 @default.
• W2898903301 cites W2049796714 @default.
• W2898903301 cites W2057966419 @default.
• W2898903301 cites W2062614245 @default.
• W2898903301 cites W2065634561 @default.
• W2898903301 cites W2076978846 @default.
• W2898903301 cites W2084670210 @default.
• W2898903301 cites W2087335380 @default.
• W2898903301 cites W2095157077 @default.
• W2898903301 cites W2097458597 @default.
• W2898903301 cites W2097972057 @default.
• W2898903301 cites W2103191975 @default.
• W2898903301 cites W2111329073 @default.
• W2898903301 cites W2125244516 @default.
• W2898903301 cites W2125734610 @default.
• W2898903301 cites W2126072003 @default.
• W2898903301 cites W2128296469 @default.
• W2898903301 cites W2130590450 @default.
• W2898903301 cites W2140167385 @default.
• W2898903301 cites W2145368514 @default.
• W2898903301 cites W2148733715 @default.
• W2898903301 cites W2254547511 @default.
• W2898903301 cites W2328448114 @default.
• W2898903301 cites W2343168296 @default.
• W2898903301 cites W2736585052 @default.
• W2898903301 cites W1972433864 @default.
• W2898903301 doi "https://doi.org/10.1016/j.tox.2018.10.020" @default.
• W2898903301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30391266" @default.
• W2898903301 hasPublicationYear "2019" @default.
• W2898903301 type Work @default.
• W2898903301 sameAs 2898903301 @default.
• W2898903301 citedByCount "31" @default.
• W2898903301 countsByYear W28989033012020 @default.
• W2898903301 countsByYear W28989033012021 @default.
• W2898903301 countsByYear W28989033012022 @default.
• W2898903301 countsByYear W28989033012023 @default.
• W2898903301 crossrefType "journal-article" @default.
• W2898903301 hasAuthorship W2898903301A5001693600 @default.
• W2898903301 hasAuthorship W2898903301A5005589098 @default.
• W2898903301 hasAuthorship W2898903301A5006256505 @default.
• W2898903301 hasAuthorship W2898903301A5014039664 @default.
• W2898903301 hasAuthorship W2898903301A5034480243 @default.
• W2898903301 hasAuthorship W2898903301A5060410353 @default.
• W2898903301 hasAuthorship W2898903301A5060598412 @default.
• W2898903301 hasAuthorship W2898903301A5071319862 @default.
• W2898903301 hasAuthorship W2898903301A5077937235 @default.
• W2898903301 hasAuthorship W2898903301A5088772562 @default.
• W2898903301 hasAuthorship W2898903301A5091243949 @default.
• W2898903301 hasConcept C126322002 @default.
• W2898903301 hasConcept C134018914 @default.
• W2898903301 hasConcept C16685009 @default.
• W2898903301 hasConcept C185592680 @default.
• W2898903301 hasConcept C2777736315 @default.
• W2898903301 hasConcept C2778575703 @default.
• W2898903301 hasConcept C2779279991 @default.
• W2898903301 hasConcept C71315377 @default.
• W2898903301 hasConcept C71924100 @default.
• W2898903301 hasConcept C86803240 @default.
• W2898903301 hasConceptScore W2898903301C126322002 @default.
• W2898903301 hasConceptScore W2898903301C134018914 @default.
• W2898903301 hasConceptScore W2898903301C16685009 @default.
• W2898903301 hasConceptScore W2898903301C185592680 @default.
• W2898903301 hasConceptScore W2898903301C2777736315 @default.
• W2898903301 hasConceptScore W2898903301C2778575703 @default.
• W2898903301 hasConceptScore W2898903301C2779279991 @default.
• W2898903301 hasConceptScore W2898903301C71315377 @default.
• W2898903301 hasConceptScore W2898903301C71924100 @default.

• next